Chemical modifications of intraerythrocytic hemoglobin have been obtained by reaction of β 93 sulfhydryl groups with disulfides i.e. cystamine and cystine-dimethylester. The respiratory properties of the modified erythrocytes are similar to those of the hemoglobin reacted with the same reagents and the changes observed are the same for both compounds. Although other properties of the erythrocytes are modified, the resistance to hemolysis is not vastly impaired. The results suggest the possibility of using these compounds (or similar ones) to modify red cells for therapeutical purposes
Antonini, E., Ioppolo, C., Giardina, B., Brunori, M., CHEMICAL MODIFICATIONS OF SH-GROUPS OF INTRAERYTHROCYTIC HEMOGLOBIN, <<BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS>>, 1977; 74 (4): 1647-1655 [http://hdl.handle.net/10807/6835]
CHEMICAL MODIFICATIONS OF SH-GROUPS OF INTRAERYTHROCYTIC HEMOGLOBIN
Giardina, Bruno;
1977
Abstract
Chemical modifications of intraerythrocytic hemoglobin have been obtained by reaction of β 93 sulfhydryl groups with disulfides i.e. cystamine and cystine-dimethylester. The respiratory properties of the modified erythrocytes are similar to those of the hemoglobin reacted with the same reagents and the changes observed are the same for both compounds. Although other properties of the erythrocytes are modified, the resistance to hemolysis is not vastly impaired. The results suggest the possibility of using these compounds (or similar ones) to modify red cells for therapeutical purposes
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