Tauroursodeoxycholic acid (TUDCA) is a hydrophilic bile acid that is produced in the liver and used for treatment of chronic cholestatic liver diseases. Experimental studies suggest that TUDCA may have cytoprotective and anti-apoptotic action, with potential neuroprotective activity. A proof of principle approach was adopted to provide preliminary data regarding the efficacy and tolerability of TUDCA in a series of patients with amyotrophic lateral sclerosis (ALS).

Elia, A. E., Lalli, S., Monsurrò, M., Sagnelli, A., Taiello, A., Reggiori, B., La Bella, V., Tedeschi, G., Albanese, A., Tauroursodeoxycholic acid in the treatment of patients with amyotrophic lateral sclerosis, <<EUROPEAN JOURNAL OF NEUROLOGY>>, 2015; (N/A): N/A-N/A. [doi:10.1111/ene.12664] [http://hdl.handle.net/10807/66605]

Tauroursodeoxycholic acid in the treatment of patients with amyotrophic lateral sclerosis

Elia, Antonio Emanuele;Albanese, Alberto
2015

Abstract

Tauroursodeoxycholic acid (TUDCA) is a hydrophilic bile acid that is produced in the liver and used for treatment of chronic cholestatic liver diseases. Experimental studies suggest that TUDCA may have cytoprotective and anti-apoptotic action, with potential neuroprotective activity. A proof of principle approach was adopted to provide preliminary data regarding the efficacy and tolerability of TUDCA in a series of patients with amyotrophic lateral sclerosis (ALS).
Inglese
Elia, A. E., Lalli, S., Monsurrò, M., Sagnelli, A., Taiello, A., Reggiori, B., La Bella, V., Tedeschi, G., Albanese, A., Tauroursodeoxycholic acid in the treatment of patients with amyotrophic lateral sclerosis, <<EUROPEAN JOURNAL OF NEUROLOGY>>, 2015; (N/A): N/A-N/A. [doi:10.1111/ene.12664] [http://hdl.handle.net/10807/66605]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/66605
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