Cancer stem cells (CSC) represent a rare fraction of cancer cells characterized by resistance to chemotherapy and radiation, therefore nowadays there is great need to develop new targeted therapies for brain tumors and our study aim to target pivotal transmembrane receptors such as Notch, EGFR and PDGFR, which are already under investigation in clinical trials setting for the treatment of Glioblastoma Multiforme (GBM).
Cenciarelli, C., Marei, H., Zonfrillo, M., Pierimarchi, P., Paldino, E., Casalbore, P., Felsani, A., Vescovi, A., Maira, G., Mangiola, A., PDGF receptor alpha inhibition induces apoptosis in glioblastoma cancer stem cells refractory to anti-Notch and anti-EGFR treatment, <<MOLECULAR CANCER>>, 2014; 13 (Novembre): 247-N/A. [doi:10.1186/1476-4598-13-247] [http://hdl.handle.net/10807/65970]
PDGF receptor alpha inhibition induces apoptosis in glioblastoma cancer stem cells refractory to anti-Notch and anti-EGFR treatment
Maira, Giulio;Mangiola, Annunziato
2014
Abstract
Cancer stem cells (CSC) represent a rare fraction of cancer cells characterized by resistance to chemotherapy and radiation, therefore nowadays there is great need to develop new targeted therapies for brain tumors and our study aim to target pivotal transmembrane receptors such as Notch, EGFR and PDGFR, which are already under investigation in clinical trials setting for the treatment of Glioblastoma Multiforme (GBM).
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