In this report, we demonstrate that SigL is posttranslationally regulated by a specific anti-sigma factor, RslA, and contributes to the expression of at least 28 genes. Several of these genes could mediate important cell envelope-related processes. Importantly, a sigL-rslA mutant strain was significantly attenuated in a mouse model of infection.

Dainese, E., Rodrigue, S., Delogu, G., Provvedi, R., Laflamme, L., Brzezinski, R., Fadda, G., Smith, I., Gaudreau, L., Palù, G., Manganelli, R., Posttranslational regulation of Mycobacterium tuberculosis extracytoplasmic-function sigma factor sigma L and roles in virulence and in global regulation of gene expression, <<INFECTION AND IMMUNITY>>, 2006; 74 (4): 2457-2461. [doi:10.1128/IAI.74.4.2457-2461.2006] [http://hdl.handle.net/10807/6594]

Posttranslational regulation of Mycobacterium tuberculosis extracytoplasmic-function sigma factor sigma L and roles in virulence and in global regulation of gene expression

Delogu, Giovanni;Fadda, Giovanni;
2006

Abstract

In this report, we demonstrate that SigL is posttranslationally regulated by a specific anti-sigma factor, RslA, and contributes to the expression of at least 28 genes. Several of these genes could mediate important cell envelope-related processes. Importantly, a sigL-rslA mutant strain was significantly attenuated in a mouse model of infection.
2006
Inglese
Dainese, E., Rodrigue, S., Delogu, G., Provvedi, R., Laflamme, L., Brzezinski, R., Fadda, G., Smith, I., Gaudreau, L., Palù, G., Manganelli, R., Posttranslational regulation of Mycobacterium tuberculosis extracytoplasmic-function sigma factor sigma L and roles in virulence and in global regulation of gene expression, <<INFECTION AND IMMUNITY>>, 2006; 74 (4): 2457-2461. [doi:10.1128/IAI.74.4.2457-2461.2006] [http://hdl.handle.net/10807/6594]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/6594
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