Epilepsy affects approximately 3 % of the world's population, and sudden death is a significant cause of death in this population. Sudden unexpected death in epilepsy (SUDEP) accounts for up to 17 % of all these cases, which increases the rate of sudden death by 24-fold as compared to the general population. The underlying mechanisms are still not elucidated, but recent studies suggest the possibility that a common genetic channelopathy might contribute to both epilepsy and cardiac disease to increase the incidence of death via a lethal cardiac arrhythmia. We performed genetic testing in a large cohort of individuals with epilepsy and cardiac conduction disorders in order to identify genetic mutations that could play a role in the mechanism of sudden death. Putative pathogenic disease-causing mutations in genes encoding cardiac ion channel were detected in 24 % of unrelated individuals with epilepsy. Segregation analysis through genetic screening of the available family members and functional studies are crucial tasks to understand and to prove the possible pathogenicity of the variant, but in our cohort, only two families were available. Despite further research should be performed to clarify the mechanism of coexistence of both clinical conditions, genetic analysis, applied also in post-mortem setting, could be very useful to identify genetic factors that predispose epileptic patients to sudden death, helping to prevent sudden death in patients with epilepsy.

Partemi, S., Vidal, M., Striano, P., Campuzano, O., Allegue, C., Pezzella, M., Elia, M., Parisi, P., Belcastro, V., Casellato, S., Giordano, L., Mastrangelo, M., Pietrafusa, N., Striano, S., Zara, F., Bianchi, A., Buti, D., La Neve, A., Tassinari, C., Oliva, A., Brugada, R., Genetic and forensic implications in epilepsy and cardiac arrhythmias: a case series, <<INTERNATIONAL JOURNAL OF LEGAL MEDICINE>>, 2015; 129 (3): 495-504. [doi:10.1007/s00414-014-1063-4] [http://hdl.handle.net/10807/65929]

Genetic and forensic implications in epilepsy and cardiac arrhythmias: a case series

Oliva, Antonio;
2015

Abstract

Epilepsy affects approximately 3 % of the world's population, and sudden death is a significant cause of death in this population. Sudden unexpected death in epilepsy (SUDEP) accounts for up to 17 % of all these cases, which increases the rate of sudden death by 24-fold as compared to the general population. The underlying mechanisms are still not elucidated, but recent studies suggest the possibility that a common genetic channelopathy might contribute to both epilepsy and cardiac disease to increase the incidence of death via a lethal cardiac arrhythmia. We performed genetic testing in a large cohort of individuals with epilepsy and cardiac conduction disorders in order to identify genetic mutations that could play a role in the mechanism of sudden death. Putative pathogenic disease-causing mutations in genes encoding cardiac ion channel were detected in 24 % of unrelated individuals with epilepsy. Segregation analysis through genetic screening of the available family members and functional studies are crucial tasks to understand and to prove the possible pathogenicity of the variant, but in our cohort, only two families were available. Despite further research should be performed to clarify the mechanism of coexistence of both clinical conditions, genetic analysis, applied also in post-mortem setting, could be very useful to identify genetic factors that predispose epileptic patients to sudden death, helping to prevent sudden death in patients with epilepsy.
Inglese
Partemi, S., Vidal, M., Striano, P., Campuzano, O., Allegue, C., Pezzella, M., Elia, M., Parisi, P., Belcastro, V., Casellato, S., Giordano, L., Mastrangelo, M., Pietrafusa, N., Striano, S., Zara, F., Bianchi, A., Buti, D., La Neve, A., Tassinari, C., Oliva, A., Brugada, R., Genetic and forensic implications in epilepsy and cardiac arrhythmias: a case series, <<INTERNATIONAL JOURNAL OF LEGAL MEDICINE>>, 2015; 129 (3): 495-504. [doi:10.1007/s00414-014-1063-4] [http://hdl.handle.net/10807/65929]
File in questo prodotto:
File Dimensione Formato  
65929.pdf

non disponibili

Tipologia file ?: Versione Editoriale (PDF)
Licenza: Non specificato
Dimensione 450 kB
Formato Unknown
450 kB Unknown   Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/65929
Citazioni
  • ???jsp.display-item.citation.pmc??? 19
  • Scopus 38
  • ???jsp.display-item.citation.isi??? 31
social impact