OBJECTIVE: To evaluate the effectiveness of seasonal influenza vaccine in preventing Emergency Department (ED) visits and hospitalisations for influenza like illness (ILI) in children. METHODS: We conducted a test negative case-control study during the 2011-2012 and 2012-2013 influenza seasons. Eleven paediatric hospital/wards in seven Italian regions participated in the study. Consecutive children visiting the ED with an ILI, as diagnosed by the doctor according to the European Centre for Disease Control case definition, were eligible for the study. Data were collected from trained pharmacists/physicians by interviewing parents during the ED visit (or hospital admission) of their children. An influenza microbiological test (RT-PCR) was carried out in all children. RESULTS: Seven-hundred and four children, from 6 months to 16 years of age, were enrolled: 262 children tested positive for one of the influenza viruses (cases) and 442 tested negative (controls). Cases were older than controls (median age 46 vs. 29 months), though with a similar prevalence of chronic conditions. Only 25 children (4%) were vaccinated in the study period. The overall age-adjusted vaccine effectiveness (VE) was 38% (95% confidence interval -52% to 75%). A higher VE was estimated for hospitalised children (53%; 95% confidence interval -45% to 85%). DISCUSSION: This study supports the effectiveness of the seasonal influenza vaccine in preventing visits to the EDs and hospitalisations for ILI in children, although the estimates were not statistically significant and with wide confidence intervals. Future systematic reviews of available data will provide more robust evidence for recommending influenza vaccination in children.

Mores, N., Romagnoli, C., Chiaretti, A., Compagnone, A., Riccardi, R., Delogu, G., Sali, M., Menniti Ippolito, F., Da Cas, R., Traversa, G., Santuccio, C., Trotta, F., Felicetti, P., Tartaglia, L., Di Pietro, P., Barabino, P., Renna, S., Riceputi, L., Tovo, P., Gabiano, C., Baroero, L., Le Serre, D., Virano, S., Perilongo, G., Daverio, M., Gnoato, E., Maretti, M., Manuela, O., Galeazzo, B., Rubin, G., Scanferla, S., Da Dalt, L., Stefani, C., Zerbinati, C., Chiappini, E., Sollai, S., De Martino, M., Mannelli, F., Becciani, S., Giacalone, M., Montano, S., Remaschi, G., Stival, A., Furbetta, M., Abate, P., Leonardi, I., Pirozzi, N., Raucci, U., Reale, A., Rossi, R., Russo, C., Mancinelli, L., Carlo, C., Prete, V., Tipo, V., Dinardo, M., Auricchio, F., Polimeno, T., Vaccine effectiveness against severe laboratory-confirmed influenza in children: results of two consecutive seasons in Italy., <<VACCINE>>, 2014; 2014 (35): 4466-4470. [doi:10.1016/j.vaccine.2014.06.048.] [http://hdl.handle.net/10807/65040]

Vaccine effectiveness against severe laboratory-confirmed influenza in children: results of two consecutive seasons in Italy.

Mores, Nadia;Romagnoli, Costantino;Chiaretti, Antonio;Compagnone, Adele;Riccardi, Riccardo;Delogu, Giovanni;Sali, Michela;
2014

Abstract

OBJECTIVE: To evaluate the effectiveness of seasonal influenza vaccine in preventing Emergency Department (ED) visits and hospitalisations for influenza like illness (ILI) in children. METHODS: We conducted a test negative case-control study during the 2011-2012 and 2012-2013 influenza seasons. Eleven paediatric hospital/wards in seven Italian regions participated in the study. Consecutive children visiting the ED with an ILI, as diagnosed by the doctor according to the European Centre for Disease Control case definition, were eligible for the study. Data were collected from trained pharmacists/physicians by interviewing parents during the ED visit (or hospital admission) of their children. An influenza microbiological test (RT-PCR) was carried out in all children. RESULTS: Seven-hundred and four children, from 6 months to 16 years of age, were enrolled: 262 children tested positive for one of the influenza viruses (cases) and 442 tested negative (controls). Cases were older than controls (median age 46 vs. 29 months), though with a similar prevalence of chronic conditions. Only 25 children (4%) were vaccinated in the study period. The overall age-adjusted vaccine effectiveness (VE) was 38% (95% confidence interval -52% to 75%). A higher VE was estimated for hospitalised children (53%; 95% confidence interval -45% to 85%). DISCUSSION: This study supports the effectiveness of the seasonal influenza vaccine in preventing visits to the EDs and hospitalisations for ILI in children, although the estimates were not statistically significant and with wide confidence intervals. Future systematic reviews of available data will provide more robust evidence for recommending influenza vaccination in children.
Inglese
Mores, N., Romagnoli, C., Chiaretti, A., Compagnone, A., Riccardi, R., Delogu, G., Sali, M., Menniti Ippolito, F., Da Cas, R., Traversa, G., Santuccio, C., Trotta, F., Felicetti, P., Tartaglia, L., Di Pietro, P., Barabino, P., Renna, S., Riceputi, L., Tovo, P., Gabiano, C., Baroero, L., Le Serre, D., Virano, S., Perilongo, G., Daverio, M., Gnoato, E., Maretti, M., Manuela, O., Galeazzo, B., Rubin, G., Scanferla, S., Da Dalt, L., Stefani, C., Zerbinati, C., Chiappini, E., Sollai, S., De Martino, M., Mannelli, F., Becciani, S., Giacalone, M., Montano, S., Remaschi, G., Stival, A., Furbetta, M., Abate, P., Leonardi, I., Pirozzi, N., Raucci, U., Reale, A., Rossi, R., Russo, C., Mancinelli, L., Carlo, C., Prete, V., Tipo, V., Dinardo, M., Auricchio, F., Polimeno, T., Vaccine effectiveness against severe laboratory-confirmed influenza in children: results of two consecutive seasons in Italy., <<VACCINE>>, 2014; 2014 (35): 4466-4470. [doi:10.1016/j.vaccine.2014.06.048.] [http://hdl.handle.net/10807/65040]
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