CpG oligodeoxynucleotides have been previously shown to enhance antimycobacterial response in human monocytes/macrophages. The present study reports evidences showing the capability of CpG oligodeoxynucleotides to induce (i) host phospholipase D (PLD) activation, (ii) PLD dependent reactive oxygen intermediate production, (iii) PLD dependent phagolysosome maturation and (iv) PLD dependent intracellular mycobacterial killing in type II alveolar epithelial cells. These are the first evidences showing that alveolar epithelial cells may represent efficient effecter cells during primary innate antimycobacterial immune response.

Papi, M., De Spirito, M., CpG oligodeoxinucleotides promote phospholipase D despendent phagolysosome maturation and intracellular mycobacterial killing in M. tubercolosis infected type II alveolar epithelial cells, <<CELLULAR IMMUNOLOGY>>, 2009; 259 (1): 1-4 [http://hdl.handle.net/10807/6500]

CpG oligodeoxinucleotides promote phospholipase D despendent phagolysosome maturation and intracellular mycobacterial killing in M. tubercolosis infected type II alveolar epithelial cells

Papi, Massimiliano;De Spirito, Marco
2009

Abstract

CpG oligodeoxynucleotides have been previously shown to enhance antimycobacterial response in human monocytes/macrophages. The present study reports evidences showing the capability of CpG oligodeoxynucleotides to induce (i) host phospholipase D (PLD) activation, (ii) PLD dependent reactive oxygen intermediate production, (iii) PLD dependent phagolysosome maturation and (iv) PLD dependent intracellular mycobacterial killing in type II alveolar epithelial cells. These are the first evidences showing that alveolar epithelial cells may represent efficient effecter cells during primary innate antimycobacterial immune response.
Inglese
Papi, M., De Spirito, M., CpG oligodeoxinucleotides promote phospholipase D despendent phagolysosome maturation and intracellular mycobacterial killing in M. tubercolosis infected type II alveolar epithelial cells, <>, 2009; 259 (1): 1-4 [http://hdl.handle.net/10807/6500]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/6500
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact