Ischemic heart disease is the leading cause of serious morbidity and mortality in Western society. One of the therapeutic approaches is based on the use of thrombolitic drugs that promote clot lysis. Even if the mechanisms leading to clot lysis are not completely understood, it is widely accepted that they depend on the complex biochemical reactions that occur among fibrin fibers and fibrinolitic agents, and by their ready diffusion into the fibers. Here we investigate the effects of specific anions on the architecture of protofibrils within fibrin fibers in fibrin gels prepared in a para-physiological solution. The results obtained through small-angle X-ray scattering (SAXS) demonstrate that the characteristic axial and longitudinal repeat distances among protofibrils are strongly affected by the action of Cl- and F- anions.

Missori, M., Papi, M., Maulucci, G., Arcovito, G., De Spirito, M., CL(-) and F(-) anions regulate the architecture of protofibrils in fibrin gel, <<EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS>>, 2010; 2009 (39): 1001-1006 [http://hdl.handle.net/10807/6499]

CL(-) and F(-) anions regulate the architecture of protofibrils in fibrin gel

Missori, Mauro;Papi, Massimiliano;Maulucci, Giuseppe;Arcovito, Giuseppe;De Spirito, Marco
2010

Abstract

Ischemic heart disease is the leading cause of serious morbidity and mortality in Western society. One of the therapeutic approaches is based on the use of thrombolitic drugs that promote clot lysis. Even if the mechanisms leading to clot lysis are not completely understood, it is widely accepted that they depend on the complex biochemical reactions that occur among fibrin fibers and fibrinolitic agents, and by their ready diffusion into the fibers. Here we investigate the effects of specific anions on the architecture of protofibrils within fibrin fibers in fibrin gels prepared in a para-physiological solution. The results obtained through small-angle X-ray scattering (SAXS) demonstrate that the characteristic axial and longitudinal repeat distances among protofibrils are strongly affected by the action of Cl- and F- anions.
Inglese
Missori, M., Papi, M., Maulucci, G., Arcovito, G., De Spirito, M., CL(-) and F(-) anions regulate the architecture of protofibrils in fibrin gel, <<EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS>>, 2010; 2009 (39): 1001-1006 [http://hdl.handle.net/10807/6499]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/6499
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