Alterations of B cell subset distribution have been described in the peripheral blood (PB) of rheumatoid arthritis (RA) patients, but no data are available on differences between the onset and the established phases of the disease. The purpose of the study was to clarify whether a peculiar distribution of B cell subsets characterizes RA onset, thus leading to a more favorable clinical response to treatment, and to evaluate the possible association of a particular B cell subpopulation with response to therapy.
Fedele, A. L., Tolusso, B., Gremese, E., Bosello, S. L., Carbonella, A., Canestri, S., Ferraccioli, G., Memory B cell subsets and plasmablasts are lower in early than in long-standing rheumatoid arthritis, <<BMC IMMUNOLOGY>>, 2014; 15 (Settembre): 28-28. [doi:10.1186/s12865-014-0028-1] [http://hdl.handle.net/10807/64933]
Memory B cell subsets and plasmablasts are lower in early than in long-standing rheumatoid arthritis
Fedele, Anna Laura;Tolusso, Barbara;Gremese, Elisa;Bosello, Silvia Laura;Carbonella, Angela;Ferraccioli, Gianfranco
2014
Abstract
Alterations of B cell subset distribution have been described in the peripheral blood (PB) of rheumatoid arthritis (RA) patients, but no data are available on differences between the onset and the established phases of the disease. The purpose of the study was to clarify whether a peculiar distribution of B cell subsets characterizes RA onset, thus leading to a more favorable clinical response to treatment, and to evaluate the possible association of a particular B cell subpopulation with response to therapy.
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