Multiple sclerosis-related fatigue is highly common and often refractory to medical therapy. Ten fatigued multiple sclerosis patients received two blocks of 5-day anodal bilateral primary somatosensory areas transcranial direct current stimulation in a randomized, double-blind sham-controlled, cross-over study. The real neuromodulation by a personalized electrode, shaped on the MR-derived primary somatosensory cortical strip, reduced fatigue in all patients, by 26 % in average (p = 0.002), which did not change after sham (p = 0.901). Anodal tDCS over bilateral somatosensory areas was able to relief fatigue in mildly disabled MS patients, when the fatigue-related symptoms severely hamper their quality of life. These small-scale study results support the concept that interventions modifying the sensorimotor network activity balances could be a suitable non-pharmacological treatment for multiple sclerosis fatigue.

Tecchio, F., Cancelli, A., Cottone, C., Zito, G., Pasqualetti, P., Ghazaryan, A., Rossini, P. M., Filippi, M., Multiple sclerosis fatigue relief by bilateral somatosensory cortex neuromodulation, <<JOURNAL OF NEUROLOGY>>, 2014; 261 (8): 1552-1558. [doi:10.1007/s00415-014-7377-9] [http://hdl.handle.net/10807/63948]

Multiple sclerosis fatigue relief by bilateral somatosensory cortex neuromodulation

Rossini, Paolo Maria;
2014

Abstract

Multiple sclerosis-related fatigue is highly common and often refractory to medical therapy. Ten fatigued multiple sclerosis patients received two blocks of 5-day anodal bilateral primary somatosensory areas transcranial direct current stimulation in a randomized, double-blind sham-controlled, cross-over study. The real neuromodulation by a personalized electrode, shaped on the MR-derived primary somatosensory cortical strip, reduced fatigue in all patients, by 26 % in average (p = 0.002), which did not change after sham (p = 0.901). Anodal tDCS over bilateral somatosensory areas was able to relief fatigue in mildly disabled MS patients, when the fatigue-related symptoms severely hamper their quality of life. These small-scale study results support the concept that interventions modifying the sensorimotor network activity balances could be a suitable non-pharmacological treatment for multiple sclerosis fatigue.
Inglese
Tecchio, F., Cancelli, A., Cottone, C., Zito, G., Pasqualetti, P., Ghazaryan, A., Rossini, P. M., Filippi, M., Multiple sclerosis fatigue relief by bilateral somatosensory cortex neuromodulation, <<JOURNAL OF NEUROLOGY>>, 2014; 261 (8): 1552-1558. [doi:10.1007/s00415-014-7377-9] [http://hdl.handle.net/10807/63948]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/63948
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