In a phase I/II trial, patients with locally advanced rectal cancer received preoperative radiotherapy (RT) and concurrent with 5-fluorouracil (5-FU) and gefitinib. Results were promising. To elucidate the molecular and biological effects, we replicated the schedule in the LoVo human colorectal adenocarcinoma cell line.

Palumbo, I., Piattoni, S., Valentini, V., Marini, V., Contavalli, P., Calzuola, M., Vecchio, F. M., Cecchini, D., Falzetti, F., Aristei, C., Gefitinib enhances the effects of combined radiotherapy and 5-fluorouracil in a colorectal cancer cell line, <<INTERNATIONAL JOURNAL OF COLORECTAL DISEASE>>, 2014; 29 (1): 31-41. [doi:10.1007/s00384-013-1754-1] [http://hdl.handle.net/10807/63822]

Gefitinib enhances the effects of combined radiotherapy and 5-fluorouracil in a colorectal cancer cell line

Valentini, Vincenzo;Vecchio, Fabio Maria;
2014

Abstract

In a phase I/II trial, patients with locally advanced rectal cancer received preoperative radiotherapy (RT) and concurrent with 5-fluorouracil (5-FU) and gefitinib. Results were promising. To elucidate the molecular and biological effects, we replicated the schedule in the LoVo human colorectal adenocarcinoma cell line.
2014
Inglese
Palumbo, I., Piattoni, S., Valentini, V., Marini, V., Contavalli, P., Calzuola, M., Vecchio, F. M., Cecchini, D., Falzetti, F., Aristei, C., Gefitinib enhances the effects of combined radiotherapy and 5-fluorouracil in a colorectal cancer cell line, <<INTERNATIONAL JOURNAL OF COLORECTAL DISEASE>>, 2014; 29 (1): 31-41. [doi:10.1007/s00384-013-1754-1] [http://hdl.handle.net/10807/63822]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/63822
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