Osteoprotegerin (OPG) is a secretory glycoprotein that belongs to the tumor necrosis factor receptor family and plays a role in atherosclerosis. OPG has been hypothesized to modulate vascular functions; however, its role in mediating atherosclerosis is controversial. Epidemiological data in patients with cardiovascular disease (CVD) indicate that OPG serum levels are associated with several inflammatory markers, myocardial infarction events, and calcium scores, suggesting that OPG may be causative for CVD.
Biscetti, F., Bertucci, F., Straface, G., Santoliquido, A., Tondi, P., Angelini, F., Pitocco, D., Santoro, L., Gasbarrini, A., Landolfi, R., Flex, A., TNFRSF11B gene polymorphisms increased risk of peripheral arterial occlusive disease and critical limb ischemia in patients with type 2 diabetes, <<ACTA DIABETOLOGICA>>, 2014; 51 (6): 1025-1032. [doi:10.1007/s00592-014-0664-1] [http://hdl.handle.net/10807/63660]
TNFRSF11B gene polymorphisms increased risk of peripheral arterial occlusive disease and critical limb ischemia in patients with type 2 diabetes
Biscetti, Federico;Bertucci, Flavio;Straface, Giuseppe;Santoliquido, Angelo;Tondi, Paolo;Angelini, Flavia;Pitocco, Dario;Santoro, Luca;Gasbarrini, Antonio;Landolfi, Raffaele;Flex, Andrea
2014
Abstract
Osteoprotegerin (OPG) is a secretory glycoprotein that belongs to the tumor necrosis factor receptor family and plays a role in atherosclerosis. OPG has been hypothesized to modulate vascular functions; however, its role in mediating atherosclerosis is controversial. Epidemiological data in patients with cardiovascular disease (CVD) indicate that OPG serum levels are associated with several inflammatory markers, myocardial infarction events, and calcium scores, suggesting that OPG may be causative for CVD.
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