Introduction The Y-box binding protein-1 (YB-1) is a multifunctional oncoprotein involved in the proliferation and aggressiveness of cancer cells. The aim of this study was to determine whether strong YB-1 expression in neoplastic cells of colorectal liver metastases (CRLM) may have an impact on liver disease-free survival following liver resection. Materials and Methods Immunohistochemistry was performed to evaluate YB-1 in 66 patients who underwent liver resection for CRLM. YB-1 expression was classified as weak (low-staining intensity) and strong (high-staining intensity). Results YB-1 expression was observed in the cytoplasm of all CRLM. YB-1 expression was weak in 17 patients (25.8 %) and strong in 49 patients (74.2 %). Liver recurrence rate was significantly higher in the strong than in the weak expression group: 55.1 vs. 23.5%(p=0.023).Multivariable logistic regression analysis showed that YB-1 strong expression was the only independent risk factor for liver recurrence. The 5-year specific liver disease-free survival rate was 76.0 % in the weak expression group and 41.5 % in the strong expression group (p=0.034). These results were not influenced by clinical prognostic factors of tumor recurrence. Conclusions This is the first study showing that the degree of YB-1 expression in tissue specimens of CRLM predicts liver recurrence following liver resection

Ardito, F., Arena, V., Vellone, M., Pennacchia, I., Majellaro, F., Giovannini, I., Vecchio, F. M., Nuzzo, G., Giuliante, F., Strong YB-1 expression predicts liver recurrence following resection for colorectal metastases, <<JOURNAL OF GASTROINTESTINAL SURGERY>>, 2014; 18 (11): 1987-1993. [doi:10.1007/s11605-014-2657-3] [http://hdl.handle.net/10807/63597]

Strong YB-1 expression predicts liver recurrence following resection for colorectal metastases

Ardito, Francesco;Arena, Vincenzo;Vellone, Maria;Pennacchia, Ilaria;Giovannini, Ivo;Vecchio, Fabio Maria;Nuzzo, Gennaro;Giuliante, Felice
2014

Abstract

Introduction The Y-box binding protein-1 (YB-1) is a multifunctional oncoprotein involved in the proliferation and aggressiveness of cancer cells. The aim of this study was to determine whether strong YB-1 expression in neoplastic cells of colorectal liver metastases (CRLM) may have an impact on liver disease-free survival following liver resection. Materials and Methods Immunohistochemistry was performed to evaluate YB-1 in 66 patients who underwent liver resection for CRLM. YB-1 expression was classified as weak (low-staining intensity) and strong (high-staining intensity). Results YB-1 expression was observed in the cytoplasm of all CRLM. YB-1 expression was weak in 17 patients (25.8 %) and strong in 49 patients (74.2 %). Liver recurrence rate was significantly higher in the strong than in the weak expression group: 55.1 vs. 23.5%(p=0.023).Multivariable logistic regression analysis showed that YB-1 strong expression was the only independent risk factor for liver recurrence. The 5-year specific liver disease-free survival rate was 76.0 % in the weak expression group and 41.5 % in the strong expression group (p=0.034). These results were not influenced by clinical prognostic factors of tumor recurrence. Conclusions This is the first study showing that the degree of YB-1 expression in tissue specimens of CRLM predicts liver recurrence following liver resection
Inglese
Ardito, F., Arena, V., Vellone, M., Pennacchia, I., Majellaro, F., Giovannini, I., Vecchio, F. M., Nuzzo, G., Giuliante, F., Strong YB-1 expression predicts liver recurrence following resection for colorectal metastases, <<JOURNAL OF GASTROINTESTINAL SURGERY>>, 2014; 18 (11): 1987-1993. [doi:10.1007/s11605-014-2657-3] [http://hdl.handle.net/10807/63597]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/63597
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