The nanomechanical properties of SW480 colon cancer cells were investigated using Atomic Force Microscopy. SW480 cells are composed of two sub-populations with different shape and invasiveness. These two cells populations showed similar adhesion properties while appeared significantly different in term of cells stiffness. Since cell stiffness is related to invasiveness and growth, we suggest elasticity as a useful parameter to distinguish invasive cells inside the colorectal tumor bulk and the high-resolution mechanical mapping as a promising diagnostic tool for the identification of malignant cells.

Palmieri, V., Lucchetti, D., Maiorana, A., Papi, M., Maulucci, G., Ciasca, G., Svelto, M., De Spirito, M., Sgambato, A., Biomechanical investigation of colorectal cancer cells, <<APPLIED PHYSICS LETTERS>>, 2014; 105 (12): N/A-N/A. [doi:10.1063/1.4896161] [http://hdl.handle.net/10807/63008]

Biomechanical investigation of colorectal cancer cells

Palmieri, Valentina;Lucchetti, Donatella;Maiorana, Alessandro;Papi, Massimiliano;Maulucci, Giuseppe;Ciasca, Gabriele;Svelto, Maria;De Spirito, Marco;Sgambato, Alessandro
2014

Abstract

The nanomechanical properties of SW480 colon cancer cells were investigated using Atomic Force Microscopy. SW480 cells are composed of two sub-populations with different shape and invasiveness. These two cells populations showed similar adhesion properties while appeared significantly different in term of cells stiffness. Since cell stiffness is related to invasiveness and growth, we suggest elasticity as a useful parameter to distinguish invasive cells inside the colorectal tumor bulk and the high-resolution mechanical mapping as a promising diagnostic tool for the identification of malignant cells.
Inglese
Palmieri, V., Lucchetti, D., Maiorana, A., Papi, M., Maulucci, G., Ciasca, G., Svelto, M., De Spirito, M., Sgambato, A., Biomechanical investigation of colorectal cancer cells, <>, 2014; 105 (12): N/A-N/A. [doi:10.1063/1.4896161] [http://hdl.handle.net/10807/63008]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/63008
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