The effect of insulin deficiency on lipid synthesis in the liver of normal rats, diabetic rats by alloxan and pancreatectomized rats was studied in vitro using (1-14C) acetate as lipid precursor. Insulin deficiency induces an increased incorporation of (1-14C) acetate into triglycerides in rat liver. This is particularly evident in pancreatectomized rats with respect to alloxan diabetic rats. It is concluded that in experimental diabetes an atherogenous metabolic pattern is elaborated by the liver.
Greco, A., Mingrone, G., Peruzzi, E., Orlando, P., "In vitro" study of liver slices lipid (1-14C) acetate incorporation in experimental diabetes, <<EXPERIMENTAL PATHOLOGY>>, 1979; 20 (1): 6-10. [doi:10.1016/S0232-1513(81)80003-5] [http://hdl.handle.net/10807/6296]
"In vitro" study of liver slices lipid (1-14C) acetate incorporation in experimental diabetes
Mingrone, Geltrude;Orlando, Paolo
1981
Abstract
The effect of insulin deficiency on lipid synthesis in the liver of normal rats, diabetic rats by alloxan and pancreatectomized rats was studied in vitro using (1-14C) acetate as lipid precursor. Insulin deficiency induces an increased incorporation of (1-14C) acetate into triglycerides in rat liver. This is particularly evident in pancreatectomized rats with respect to alloxan diabetic rats. It is concluded that in experimental diabetes an atherogenous metabolic pattern is elaborated by the liver.
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