Tumor angiogenesis is an essential and complex process necessary for the growth of all tumors which represents a potential therapeutic target. Angiogenesis inhibitors targeting vascular endothelial growth factor (VEGF) or their receptor tyrosine kinases have been approved by the FDA. In thymic epithelial tumors (TET), targeted therapies have been sporadically applied due to their rarity. To ascertain the presence of potential therapeutic targets, we analyzed by immunohistochemistry the expression of angiogenesis-related biomarkers in a large series of TET arranged in Tissue Micro Arrays (TMA).

Lattanzio, R., La Sorda, R., Facciolo, F., Sioletic, S., Lauriola, L., Gallo, E., Palmieri, G., Evoli, A., Alessandrini, G., Ruco, L., Rendina, E., Truini, M., Chiarle, R., Barreca, A., Pich, A., Ascani, S., Remotti, D., Tunesi, G., Granone, P., Ratto, G., Puma, M., Pescarmona, E., Thymic epithelial tumors express vascular endothelial growth factors and their receptors as potential targets of antiangiogenic therapy: a tissue micro array-based multicenter study, <<LUNG CANCER>>, 2014; 85 (2): 191-196. [doi:10.1016/j.lungcan.2014.05.010] [http://hdl.handle.net/10807/62803]

Thymic epithelial tumors express vascular endothelial growth factors and their receptors as potential targets of antiangiogenic therapy: a tissue micro array-based multicenter study

Sioletic, Stefano;Lauriola, Libero;Evoli, Amelia;Granone, Pierluigi;
2014

Abstract

Tumor angiogenesis is an essential and complex process necessary for the growth of all tumors which represents a potential therapeutic target. Angiogenesis inhibitors targeting vascular endothelial growth factor (VEGF) or their receptor tyrosine kinases have been approved by the FDA. In thymic epithelial tumors (TET), targeted therapies have been sporadically applied due to their rarity. To ascertain the presence of potential therapeutic targets, we analyzed by immunohistochemistry the expression of angiogenesis-related biomarkers in a large series of TET arranged in Tissue Micro Arrays (TMA).
Inglese
Lattanzio, R., La Sorda, R., Facciolo, F., Sioletic, S., Lauriola, L., Gallo, E., Palmieri, G., Evoli, A., Alessandrini, G., Ruco, L., Rendina, E., Truini, M., Chiarle, R., Barreca, A., Pich, A., Ascani, S., Remotti, D., Tunesi, G., Granone, P., Ratto, G., Puma, M., Pescarmona, E., Thymic epithelial tumors express vascular endothelial growth factors and their receptors as potential targets of antiangiogenic therapy: a tissue micro array-based multicenter study, <<LUNG CANCER>>, 2014; 85 (2): 191-196. [doi:10.1016/j.lungcan.2014.05.010] [http://hdl.handle.net/10807/62803]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/62803
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