Chronic inflammation may play a role in prostate carcinogenesis. Molecular alterations of the Suppressor of Cytokine Signaling (SOCS)-3 can contribute to explain the pleiotropic role of interleukin (IL)-6 in this type of cancer. Recently, the methylation of SOCS3 gene has been demonstrated to cause the non-expression of the protein, being involved in the pathogenesis of prostate cancer (PC) and identifying a subset of aggressive tumors. We evaluated the expression of SOCS3 protein in patients (pt) with bioptically-diagnosed PC by immunohistochemical analysis, which is easier to perform, cheaper and more reproducible compared to DNA analysis.

Calarco, A., Pinto, F., Pierconti, F., Sacco, E., Marrucci, E., Totaro, A., Palermo, G., Vittori, M., Bassi, P., Role of SOCS3 evaluated by immunohistochemical analysis in a cohort of patients affected by prostate cancer: preliminary results, <<UROLOGIA>>, 2012; 79 Suppl 19 (Dicembre): 4-8. [doi:10.5301/RU.2012.9392] [http://hdl.handle.net/10807/62770]

Role of SOCS3 evaluated by immunohistochemical analysis in a cohort of patients affected by prostate cancer: preliminary results

Calarco, Alessandro;Pinto, Francesco;Pierconti, Francesco;Sacco, Emilio;Marrucci, Eleonora;Totaro, Angelo;Palermo, Giuseppe;Vittori, Matteo;Bassi, Pierfrancesco
2012

Abstract

Chronic inflammation may play a role in prostate carcinogenesis. Molecular alterations of the Suppressor of Cytokine Signaling (SOCS)-3 can contribute to explain the pleiotropic role of interleukin (IL)-6 in this type of cancer. Recently, the methylation of SOCS3 gene has been demonstrated to cause the non-expression of the protein, being involved in the pathogenesis of prostate cancer (PC) and identifying a subset of aggressive tumors. We evaluated the expression of SOCS3 protein in patients (pt) with bioptically-diagnosed PC by immunohistochemical analysis, which is easier to perform, cheaper and more reproducible compared to DNA analysis.
2012
Inglese
Calarco, A., Pinto, F., Pierconti, F., Sacco, E., Marrucci, E., Totaro, A., Palermo, G., Vittori, M., Bassi, P., Role of SOCS3 evaluated by immunohistochemical analysis in a cohort of patients affected by prostate cancer: preliminary results, <<UROLOGIA>>, 2012; 79 Suppl 19 (Dicembre): 4-8. [doi:10.5301/RU.2012.9392] [http://hdl.handle.net/10807/62770]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/62770
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