Reelin is a large secreted extracellular matrix glycoprotein which contributes to positioning, migration and laminar organization of several central nervous system structures during neurodevelopment. Recent studies reported the expression of Reelin and its intracellular adapter protein DAB-1 in neuroblastoma, where it is involved in cell motility and invasiveness. The aim of this study was to investigate the expression of Reelin in both tumor and peritumor tissue derived from glioblastoma (GBM), and in cancer stem cells (CSC) isolated from both tumor (GCSC) and peritumor tissue (PCSC).
Biamonte, F., D'Alessio, A., Scicchitano, B. M., Lama, G., Vescovi, A., Maira, G., Sica, G., Reelin in human Glioblastoma and in cancer stem cells isolated from tumor and peritumor tissue, Abstract de <<International Neuroscience Congress>>, (Roma, 12-13 June 2014 ), N/A, Roma 2014: 03-03 [http://hdl.handle.net/10807/62116]
Reelin in human Glioblastoma and in cancer stem cells isolated from tumor and peritumor tissue
Biamonte, Filippo;D'Alessio, Alessio;Scicchitano, Bianca Maria;Lama, Gina;Maira, Giulio;Sica, Gigliola
2014
Abstract
Reelin is a large secreted extracellular matrix glycoprotein which contributes to positioning, migration and laminar organization of several central nervous system structures during neurodevelopment. Recent studies reported the expression of Reelin and its intracellular adapter protein DAB-1 in neuroblastoma, where it is involved in cell motility and invasiveness. The aim of this study was to investigate the expression of Reelin in both tumor and peritumor tissue derived from glioblastoma (GBM), and in cancer stem cells (CSC) isolated from both tumor (GCSC) and peritumor tissue (PCSC).
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