Inherited retinal degenerations (IRDs) are an untreatable cause of blindness due to photoreceptor apoptosis. Blocking apoptosis by exogenous neurotrophic factor administration is a promising therapeutic strategy in IRDs. The neurotrophin (NT) family are a group of peptide growth factors homologous to nerve growth factor that regulate the development, differentiation, survival, and function of neuronal cells. This mini-review summarizes the preclinical evidence for neuroprotection of photoreceptors by NTs and explores the molecular pathways responsible for this protective effect.
Abed, E., Corbo, G., Falsini, B., Neurotrophin Family Members as Neuroprotectants in Retinal Degenerations, <<BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy>>, 2014; 2014 (Novembre): N/A-N/A. [doi:10.1007/s40259-014-0110-5] [http://hdl.handle.net/10807/61949]
Neurotrophin Family Members as Neuroprotectants in Retinal Degenerations
Falsini, Benedetto
2014
Abstract
Inherited retinal degenerations (IRDs) are an untreatable cause of blindness due to photoreceptor apoptosis. Blocking apoptosis by exogenous neurotrophic factor administration is a promising therapeutic strategy in IRDs. The neurotrophin (NT) family are a group of peptide growth factors homologous to nerve growth factor that regulate the development, differentiation, survival, and function of neuronal cells. This mini-review summarizes the preclinical evidence for neuroprotection of photoreceptors by NTs and explores the molecular pathways responsible for this protective effect.
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