Variant in glucokinase regulatory protein (GCKR), associated with lipid and glucose traits, has been suggested to affect fatty liver infiltration. We aimed to assess whether GCKR rs780094 C→T SNP influences the expression of steatosis, lobular inflammation and fibrosis in NAFLD patients, after correction for PNPLA3 genotype.
Petta, S., Miele, L., Bugianesi, E., Cammà, C., Rosso, C., Boccia, S., Cabibi, D., Di Marco, V., Grimaudo, S., Grieco, A., Pipitone, R., Marchesini, G., Craxì, A., Glucokinase regulatory protein gene polymorphism affects liver fibrosis in non-alcoholic fatty liver disease, <<PLOS ONE>>, 2014; 9 (2): e87523-e87523. [doi:10.1371/journal.pone.0087523] [http://hdl.handle.net/10807/61665]
Glucokinase regulatory protein gene polymorphism affects liver fibrosis in non-alcoholic fatty liver disease
Miele, Luca;Boccia, Stefania;Grieco, Antonio;
2014
Abstract
Variant in glucokinase regulatory protein (GCKR), associated with lipid and glucose traits, has been suggested to affect fatty liver infiltration. We aimed to assess whether GCKR rs780094 C→T SNP influences the expression of steatosis, lobular inflammation and fibrosis in NAFLD patients, after correction for PNPLA3 genotype.
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