Lead-time is the time by which diagnosis is anticipated by screening/surveillance with respect to the symptomatic detection of a disease. Any screening program, including surveillance for hepatocellular carcinoma (HCC), is subject to lead-time bias. Data regarding lead-time for HCC are lacking. Aims of the present study were to calculate lead-time and to assess its impact on the benefit obtainable from the surveillance of cirrhotic patients.

Cucchetti, A., Trevisani, F., Pecorelli, A., Erroi, V., Farinati, F., Ciccarese, F., Rapaccini, G., Di Marco, M., Caturelli, E., Giannini, E., Zoli, M., Borzio, F., Cabibbo, G., Felder, M., Gasbarrini, A., Sacco, R., Foschi, F., Missale, G., Morisco, F., Baroni, G., Virdone, R., Bernardi, M., Pinna, A., Grieco, A., Estimation of lead-time bias and its impact on the outcome of surveillance for the early diagnosis of hepatocellular carcinoma, <<JOURNAL OF HEPATOLOGY>>, 2014; 61 (2): 333-341. [doi:10.1016/j.jhep.2014.03.037] [http://hdl.handle.net/10807/61663]

Estimation of lead-time bias and its impact on the outcome of surveillance for the early diagnosis of hepatocellular carcinoma

Grieco, Antonio
2014

Abstract

Lead-time is the time by which diagnosis is anticipated by screening/surveillance with respect to the symptomatic detection of a disease. Any screening program, including surveillance for hepatocellular carcinoma (HCC), is subject to lead-time bias. Data regarding lead-time for HCC are lacking. Aims of the present study were to calculate lead-time and to assess its impact on the benefit obtainable from the surveillance of cirrhotic patients.
2014
Inglese
Cucchetti, A., Trevisani, F., Pecorelli, A., Erroi, V., Farinati, F., Ciccarese, F., Rapaccini, G., Di Marco, M., Caturelli, E., Giannini, E., Zoli, M., Borzio, F., Cabibbo, G., Felder, M., Gasbarrini, A., Sacco, R., Foschi, F., Missale, G., Morisco, F., Baroni, G., Virdone, R., Bernardi, M., Pinna, A., Grieco, A., Estimation of lead-time bias and its impact on the outcome of surveillance for the early diagnosis of hepatocellular carcinoma, <<JOURNAL OF HEPATOLOGY>>, 2014; 61 (2): 333-341. [doi:10.1016/j.jhep.2014.03.037] [http://hdl.handle.net/10807/61663]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/61663
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