Chronic obstructive pulmonary disease (COPD) is characterized by large phenotype variability, reflected by a highly variable response to pharmacological treatment. Nevertheless, current guidelines suggest that patients with COPD of similar severity should be treated in the same way. The phenotype-based pharmacotherapeutic approach proposes bronchodilators alone in the nonfrequent exacerbator phenotype and a combination of bronchodilators and inhaled corticosteroids in patients with asthma-COPD overlap syndrome (ACOS) and moderate-to-severe exacerbator phenotype. The clinical importance of phenotypes is changing the paradigm of COPD management from evidence-based to personalized medicine. However, the personalized pharmacological strategy of COPD has to be validated in future clinical studies

Montuschi, P., Malerba, M., Santini, G., Miravitlles, M., Pharmacological treatment of chronic obstructive pulmonary disease: from evidence-based medicine to phenotyping, <<DRUG DISCOVERY TODAY>>, 2014; 19 (Dicembre): 1928-1935. [doi:10.1016/j.drudis.2014.08.004] [http://hdl.handle.net/10807/60977]

Pharmacological treatment of chronic obstructive pulmonary disease: from evidence-based medicine to phenotyping

Montuschi, Paolo;
2014

Abstract

Chronic obstructive pulmonary disease (COPD) is characterized by large phenotype variability, reflected by a highly variable response to pharmacological treatment. Nevertheless, current guidelines suggest that patients with COPD of similar severity should be treated in the same way. The phenotype-based pharmacotherapeutic approach proposes bronchodilators alone in the nonfrequent exacerbator phenotype and a combination of bronchodilators and inhaled corticosteroids in patients with asthma-COPD overlap syndrome (ACOS) and moderate-to-severe exacerbator phenotype. The clinical importance of phenotypes is changing the paradigm of COPD management from evidence-based to personalized medicine. However, the personalized pharmacological strategy of COPD has to be validated in future clinical studies
2014
Inglese
Montuschi, P., Malerba, M., Santini, G., Miravitlles, M., Pharmacological treatment of chronic obstructive pulmonary disease: from evidence-based medicine to phenotyping, <<DRUG DISCOVERY TODAY>>, 2014; 19 (Dicembre): 1928-1935. [doi:10.1016/j.drudis.2014.08.004] [http://hdl.handle.net/10807/60977]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/60977
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