The aim of this study was to evaluate the caffeic acid (1) and ester derivatives (2-10) against Candida albicans biofilm and to investigate whether these compounds are able to inhibit the biofilm formation or destroy pre-formed biofilm. Caffeic acid ester 7, cinnamic acid ester 8 and 3,4-dihydroxybenzoic acid ester 10 are more active than fluconazole, used as reference drug, both on biofilm in formation with MIC50 values of 32, 32 and 16μg/mL, respectively, and in the early stage of biofilm formation (4h) with MIC50 values of 64, 32 and 64μg/mL, respectively. These esters result also more active than fluconazole on mature biofilm (24h), especially 8 and 10 with MIC50 values of 64μg/mL.
De Vita, D., Friggeri, L., D'Auria, F., Pandolfi, F., Piccoli, F., Panella, S., Palamara, A., Simonetti, G., Scipione, L., Di Santo, R., Costi, R., Tortorella, S., Activity of caffeic acid derivatives against Candida albicans biofilm, <<BIOORGANIC & MEDICINAL CHEMISTRY LETTERS>>, 2014; 24 (6): 1502-1505. [doi:10.1016/j.bmcl.2014.02.005] [http://hdl.handle.net/10807/60939]
Activity of caffeic acid derivatives against Candida albicans biofilm
Pandolfi, Franco;
2014
Abstract
The aim of this study was to evaluate the caffeic acid (1) and ester derivatives (2-10) against Candida albicans biofilm and to investigate whether these compounds are able to inhibit the biofilm formation or destroy pre-formed biofilm. Caffeic acid ester 7, cinnamic acid ester 8 and 3,4-dihydroxybenzoic acid ester 10 are more active than fluconazole, used as reference drug, both on biofilm in formation with MIC50 values of 32, 32 and 16μg/mL, respectively, and in the early stage of biofilm formation (4h) with MIC50 values of 64, 32 and 64μg/mL, respectively. These esters result also more active than fluconazole on mature biofilm (24h), especially 8 and 10 with MIC50 values of 64μg/mL.
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