Human mast cells (first described in 1879 by Paul Ehrlich) develop from committed precursors in the bone marrow expressing the differentiation marker CD34+ and distinct from the three other myeloid cells. Mast cells are present in various tissues especially near blood vessels, epithelia and nerves and they are activated by cross-linking of FcεRI, but also by a number of neuropeptides. NGF mediates a number of inflammatory and autoimmune states in conjunction with an increased accumulation of mast cells which appear to be involved in neuroimmune interactions and tissue inflammation. Here we report some relationships between mast cells and nerve growth factor (NGF).

Kritas, S., Saggini, A., Cerulli, G. G., Caraffa, A., Antinolfi, P., Pantalone, A., Frydas, S., Rosati, M., Tei, M., Speziali, A., Saggini, R., Pandolfi, F., Conti, P., Neuropeptide NGF mediates neuro-immune response and inflammation through mast cell activation, <<JOURNAL OF BIOLOGICAL REGULATORS & HOMEOSTATIC AGENTS>>, 2014; 28 (2): 177-181 [http://hdl.handle.net/10807/60798]

Neuropeptide NGF mediates neuro-immune response and inflammation through mast cell activation

Cerulli, Giuliano Giorgio;
2014

Abstract

Human mast cells (first described in 1879 by Paul Ehrlich) develop from committed precursors in the bone marrow expressing the differentiation marker CD34+ and distinct from the three other myeloid cells. Mast cells are present in various tissues especially near blood vessels, epithelia and nerves and they are activated by cross-linking of FcεRI, but also by a number of neuropeptides. NGF mediates a number of inflammatory and autoimmune states in conjunction with an increased accumulation of mast cells which appear to be involved in neuroimmune interactions and tissue inflammation. Here we report some relationships between mast cells and nerve growth factor (NGF).
2014
Inglese
Kritas, S., Saggini, A., Cerulli, G. G., Caraffa, A., Antinolfi, P., Pantalone, A., Frydas, S., Rosati, M., Tei, M., Speziali, A., Saggini, R., Pandolfi, F., Conti, P., Neuropeptide NGF mediates neuro-immune response and inflammation through mast cell activation, <<JOURNAL OF BIOLOGICAL REGULATORS & HOMEOSTATIC AGENTS>>, 2014; 28 (2): 177-181 [http://hdl.handle.net/10807/60798]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/60798
Citazioni
  • ???jsp.display-item.citation.pmc??? 8
  • Scopus 18
  • ???jsp.display-item.citation.isi??? 19
social impact