There is much evidence that neuropeptide substance P is involved in neurogenic inflammation and is an important neurotransmitter and neurmodulator compound. In addition, substance P plays an important role in inflammation and immunity. Macrophages can be activated by substance P which provokes the release of inflammatory compounds such as interleukins, chemokines and growth factors. Substance P is involved in the mechanism of pain through the trigeminal nerve which runs through the head, temporal and sinus cavity. Substance P also activates mast cells to release inflammatory mediators such as arachindonic acid compound, cytokines/chemokines and histamine. The release of these chemical mediators is crucial for inflammatory response. Among these mediators there are prostoglandins and leukotrines. Here we review the impact of substance P on inflammatory compounds.

Nicoletti, M., Neri, G., Maccauro, G., Tripodi, D., Varvara, G., Saggini, A., Potalivo, G., Castellani, M., Fulcheri, M., Rosati, M., Toniato, E., Caraffa, A., Antinolfi, P., Cerulli, G. G., Pandolfi, F., Galzio, R., Conti, P., Theoharides, T., Impact of neuropeptide substance P an inflammatory compound on arachidonic acid compound generation, <<INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY>>, 2012; 25 (4): 849-857. [doi:10.1177/039463201202500403] [http://hdl.handle.net/10807/60771]

Impact of neuropeptide substance P an inflammatory compound on arachidonic acid compound generation

Maccauro, Giulio;Cerulli, Giuliano Giorgio;Pandolfi, Franco;
2012

Abstract

There is much evidence that neuropeptide substance P is involved in neurogenic inflammation and is an important neurotransmitter and neurmodulator compound. In addition, substance P plays an important role in inflammation and immunity. Macrophages can be activated by substance P which provokes the release of inflammatory compounds such as interleukins, chemokines and growth factors. Substance P is involved in the mechanism of pain through the trigeminal nerve which runs through the head, temporal and sinus cavity. Substance P also activates mast cells to release inflammatory mediators such as arachindonic acid compound, cytokines/chemokines and histamine. The release of these chemical mediators is crucial for inflammatory response. Among these mediators there are prostoglandins and leukotrines. Here we review the impact of substance P on inflammatory compounds.
2012
Inglese
Nicoletti, M., Neri, G., Maccauro, G., Tripodi, D., Varvara, G., Saggini, A., Potalivo, G., Castellani, M., Fulcheri, M., Rosati, M., Toniato, E., Caraffa, A., Antinolfi, P., Cerulli, G. G., Pandolfi, F., Galzio, R., Conti, P., Theoharides, T., Impact of neuropeptide substance P an inflammatory compound on arachidonic acid compound generation, <<INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY>>, 2012; 25 (4): 849-857. [doi:10.1177/039463201202500403] [http://hdl.handle.net/10807/60771]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/60771
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