Osteoprotegerin (OPG) is a secretory glycoprotein that belongs to the tumor necrosis factor receptor family and plays a role in atherosclerosis. OPG has been hypothesized to modulate vascular functions; however, its role in mediating atherosclerosis is controversial. Epidemiological data in patients with cardiovascular disease (CVD) indicate that OPG serum levels are associated with several inflammatory markers, myocardial infarction events, and calcium scores, suggesting that OPG may be causative for CVD.

Biscetti, F., Bertucci, F., Straface, G., Santoliquido, A., Tondi, P., Angelini, F., Pitocco, D., Gasbarrini, A., Landolfi, R., Flex, A., TNFRSF11B gene polymorphisms increased risk of peripheral arterial occlusive disease and critical limb ischemia in patients with type 2 diabetes, <<ACTA DIABETOLOGICA>>, 2014; (Ottobre): 1025-1032. [doi:10.1007/s00592-014-0664-1] [http://hdl.handle.net/10807/60692]

TNFRSF11B gene polymorphisms increased risk of peripheral arterial occlusive disease and critical limb ischemia in patients with type 2 diabetes

Biscetti, Federico;Bertucci, Flavio;Straface, Giuseppe;Santoliquido, Angelo;Tondi, Paolo;Angelini, Flavia;Pitocco, Dario;Gasbarrini, Antonio;Landolfi, Raffaele;Flex, Andrea
2014

Abstract

Osteoprotegerin (OPG) is a secretory glycoprotein that belongs to the tumor necrosis factor receptor family and plays a role in atherosclerosis. OPG has been hypothesized to modulate vascular functions; however, its role in mediating atherosclerosis is controversial. Epidemiological data in patients with cardiovascular disease (CVD) indicate that OPG serum levels are associated with several inflammatory markers, myocardial infarction events, and calcium scores, suggesting that OPG may be causative for CVD.
2014
Inglese
Biscetti, F., Bertucci, F., Straface, G., Santoliquido, A., Tondi, P., Angelini, F., Pitocco, D., Gasbarrini, A., Landolfi, R., Flex, A., TNFRSF11B gene polymorphisms increased risk of peripheral arterial occlusive disease and critical limb ischemia in patients with type 2 diabetes, <<ACTA DIABETOLOGICA>>, 2014; (Ottobre): 1025-1032. [doi:10.1007/s00592-014-0664-1] [http://hdl.handle.net/10807/60692]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/60692
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