Even though the acetylation of platelet cyclooxygenase (COX)-1 at serine-529 is the direct mechanism of action of low-dose aspirin, its antiplatelet effect has been characterized using indirect indexes of COX-1 activity.

Patrignani, P., Tacconelli, S., Piazuelo, E., Di Francesco, L., Dovizio, M., Sostres, C., Marcantoni, E., Guillem Llobat, P., Del Boccio, P., Zucchelli, M., Patrono, C., Lanas, A., Reappraisal of the clinical pharmacology of low-dose aspirin by comparing novel direct and traditional indirect biomarkers of drug action, <<JOURNAL OF THROMBOSIS AND HAEMOSTASIS>>, 2014; 12 (8): 1320-1330. [doi:10.1111/jth.12637] [http://hdl.handle.net/10807/60175]

Reappraisal of the clinical pharmacology of low-dose aspirin by comparing novel direct and traditional indirect biomarkers of drug action

Patrono, Carlo;
2014

Abstract

Even though the acetylation of platelet cyclooxygenase (COX)-1 at serine-529 is the direct mechanism of action of low-dose aspirin, its antiplatelet effect has been characterized using indirect indexes of COX-1 activity.
2014
Inglese
Patrignani, P., Tacconelli, S., Piazuelo, E., Di Francesco, L., Dovizio, M., Sostres, C., Marcantoni, E., Guillem Llobat, P., Del Boccio, P., Zucchelli, M., Patrono, C., Lanas, A., Reappraisal of the clinical pharmacology of low-dose aspirin by comparing novel direct and traditional indirect biomarkers of drug action, <<JOURNAL OF THROMBOSIS AND HAEMOSTASIS>>, 2014; 12 (8): 1320-1330. [doi:10.1111/jth.12637] [http://hdl.handle.net/10807/60175]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/60175
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