Among the multiple factors concurring to Alzheimer's disease (AD) pathogenesis, greater attention should be devoted to the role played by infectious agents. Growing epidemiological and experimental evidence suggests that recurrent herpes simplex virus type-1 (HSV-1) infection is a risk factor for AD although the underlying molecular and functional mechanisms have not been fully elucidated yet. Here, we review literature suggesting the involvement of HSV-1 infection in AD also briefly mentioning possible pharmacological implications of these findings.
Piacentini, R., De Chiara, G., Li Puma, D. D., Ripoli, C., Marcocci, M. E., Garaci, E., Palamara, A. T., Grassi, C., HSV-1 and Alzheimer's disease: more than a hypothesis, <<FRONTIERS IN PHARMACOLOGY>>, 2014; 5 (Maggio): 97-97. [doi:10.3389/fphar.2014.00097] [http://hdl.handle.net/10807/59536]
HSV-1 and Alzheimer's disease: more than a hypothesis
Piacentini, Roberto;Li Puma, Domenica Donatella;Ripoli, Cristian;Marcocci, Maria Elena;Grassi, Claudio
2014
Abstract
Among the multiple factors concurring to Alzheimer's disease (AD) pathogenesis, greater attention should be devoted to the role played by infectious agents. Growing epidemiological and experimental evidence suggests that recurrent herpes simplex virus type-1 (HSV-1) infection is a risk factor for AD although the underlying molecular and functional mechanisms have not been fully elucidated yet. Here, we review literature suggesting the involvement of HSV-1 infection in AD also briefly mentioning possible pharmacological implications of these findings.
| File | Dimensione | Formato | |
|---|---|---|---|
|
Front. Pharmacol. 5, 97, 2014.pdf
accesso aperto
Tipologia file ?:
Versione Editoriale (PDF)
Licenza:
Creative commons
Dimensione
1.15 MB
Formato
Adobe PDF
|
1.15 MB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
