The basal oxidative and nitrosative stress levels measured in cytosol, mitochondria, and nuclei as well as in the whole homogenate obtained from the brain of wild type (wt) and p53 knockout [p53((-/-))] mice were evaluated. We hypothesized that the loss of p53 could trigger the activation of several protective mechanisms such as those involving thioredoxin-1 (Thio-1), the heme-oxygenase-1/biliverdin reductase-A (HO-1/BVR-A) system, manganese superoxide dismutase (MnSOD), the IkB kinase type β (IKKβ)/nuclear factor kappa-B (NF-kB), and the nuclear factor-erythroid 2 (NF-E2) related factor 2 (Nrf-2).

Barone, E., Cenini, G., Sultana, R., Di Domenico, F., Fiorini, A., Perluigi, M., Noel, T., Wang, C., Mancuso, C., St Clair, D., Butterfield, D., Lack of p53 decreases basal oxidative stress levels in the brain through upregulation of thioredoxin-1, biliverdin reductase-A, manganese superoxide dismutase, and nuclear factor kappa-B, <<ANTIOXIDANTS & REDOX SIGNALING>>, 2012; 16 (12): 1407-1420. [doi:10.1089/ars.2011.4124] [http://hdl.handle.net/10807/5906]

Lack of p53 decreases basal oxidative stress levels in the brain through upregulation of thioredoxin-1, biliverdin reductase-A, manganese superoxide dismutase, and nuclear factor kappa-B

Barone, Eugenio;Mancuso, Cesare;
2012

Abstract

The basal oxidative and nitrosative stress levels measured in cytosol, mitochondria, and nuclei as well as in the whole homogenate obtained from the brain of wild type (wt) and p53 knockout [p53((-/-))] mice were evaluated. We hypothesized that the loss of p53 could trigger the activation of several protective mechanisms such as those involving thioredoxin-1 (Thio-1), the heme-oxygenase-1/biliverdin reductase-A (HO-1/BVR-A) system, manganese superoxide dismutase (MnSOD), the IkB kinase type β (IKKβ)/nuclear factor kappa-B (NF-kB), and the nuclear factor-erythroid 2 (NF-E2) related factor 2 (Nrf-2).
2012
Inglese
Barone, E., Cenini, G., Sultana, R., Di Domenico, F., Fiorini, A., Perluigi, M., Noel, T., Wang, C., Mancuso, C., St Clair, D., Butterfield, D., Lack of p53 decreases basal oxidative stress levels in the brain through upregulation of thioredoxin-1, biliverdin reductase-A, manganese superoxide dismutase, and nuclear factor kappa-B, <<ANTIOXIDANTS & REDOX SIGNALING>>, 2012; 16 (12): 1407-1420. [doi:10.1089/ars.2011.4124] [http://hdl.handle.net/10807/5906]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/5906
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