Disodium sebacate is a 10-carbon-atom dicarboxylic acid, proposed as substrate for parenteral nutrition. We investigated its pharmacokinetic profile and thermogenic effect during a short-time infusion (5 h at 10 g/h) in 7 male volunteers. Sebacate in serum and urine was measured by high-performance liquid chromatography. A single-compartment model with two linear elimination routes was fitted. Metabolic measurements (VO2, VCO2, respiratory quotient, metabolic rate) were continuously performed for 8 h (5 h during and 3 h after the infusion) by a canopy indirect calorimeter. The apparent volume of distribution of sebacate was 8.39 +/- 0.69 liters, and the plasma fractional removal rate constant was 0.0086 +/- 0.00077 min-1. The average half-life and plasma clearance were 80.6 min and 72 ml/min, respectively. The increase in metabolic rate, the decrease in respiratory quotient and the changes in ketone body, glucagon and insulin levels during the infusion were not significant. 24-hour catecholamine excretion was within normal limits. Calories administered by sebacate seem to be available for utilization without relevant metabolic side effects.

Greco, A., Mingrone, G., Raguso, C., Tataranni, A., Finotti, E., Tacchino, R., Capristo, E., De Gaetano, A., Castagneto, M., Metabolic effects and disposition of sebacate, an alternate dicarboxylic fuel substrate, <<ANNALS OF NUTRITION AND METABOLISM>>, 1992; 36 (1): 1-11 [http://hdl.handle.net/10807/5833]

Metabolic effects and disposition of sebacate, an alternate dicarboxylic fuel substrate

Mingrone, Geltrude;Capristo, Esmeralda;De Gaetano, Andrea;Castagneto, Marco
1992

Abstract

Disodium sebacate is a 10-carbon-atom dicarboxylic acid, proposed as substrate for parenteral nutrition. We investigated its pharmacokinetic profile and thermogenic effect during a short-time infusion (5 h at 10 g/h) in 7 male volunteers. Sebacate in serum and urine was measured by high-performance liquid chromatography. A single-compartment model with two linear elimination routes was fitted. Metabolic measurements (VO2, VCO2, respiratory quotient, metabolic rate) were continuously performed for 8 h (5 h during and 3 h after the infusion) by a canopy indirect calorimeter. The apparent volume of distribution of sebacate was 8.39 +/- 0.69 liters, and the plasma fractional removal rate constant was 0.0086 +/- 0.00077 min-1. The average half-life and plasma clearance were 80.6 min and 72 ml/min, respectively. The increase in metabolic rate, the decrease in respiratory quotient and the changes in ketone body, glucagon and insulin levels during the infusion were not significant. 24-hour catecholamine excretion was within normal limits. Calories administered by sebacate seem to be available for utilization without relevant metabolic side effects.
Inglese
Greco, A., Mingrone, G., Raguso, C., Tataranni, A., Finotti, E., Tacchino, R., Capristo, E., De Gaetano, A., Castagneto, M., Metabolic effects and disposition of sebacate, an alternate dicarboxylic fuel substrate, <>, 1992; 36 (1): 1-11 [http://hdl.handle.net/10807/5833]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/5833
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