Fasting serum conjugated bile salt concentrations were measured in a group of 20 patients with moderate post-hepatitis cirrhosis. Twenty healthy volunteers were used as controls. The individual conjugated bile acids were analyzed by a specific and sensitive method which couples reversed-phase high-performance liquid chromatography with mass spectrometry. Significantly elevated levels of the total and individual conjugated bile acids were found in cirrhotic patients. The predominant serum bile acids were conjugates of chenodeoxycholic acid. The conjugates of lithocholic acid were also increased; in subjects with normal liver function, on the contrary, they were found only in traces.
Greco, A., Mingrone, G., Serum bile acid concentrations in mild liver cirrhosis, <<CLINICA CHIMICA ACTA>>, 1993; 221 (1-2): 183-189 [http://hdl.handle.net/10807/5822]
Serum bile acid concentrations in mild liver cirrhosis
Mingrone, Geltrude
1993
Abstract
Fasting serum conjugated bile salt concentrations were measured in a group of 20 patients with moderate post-hepatitis cirrhosis. Twenty healthy volunteers were used as controls. The individual conjugated bile acids were analyzed by a specific and sensitive method which couples reversed-phase high-performance liquid chromatography with mass spectrometry. Significantly elevated levels of the total and individual conjugated bile acids were found in cirrhotic patients. The predominant serum bile acids were conjugates of chenodeoxycholic acid. The conjugates of lithocholic acid were also increased; in subjects with normal liver function, on the contrary, they were found only in traces.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.