Chronic insomnia is highly prevalent in the general population, provoking personal distress and increased risk for psychiatric and medical disorders. Autonomic hyper-arousal could be a pathogenic mechanism of chronic primary insomnia. The aim of this study was to investigate autonomic activity in patients with chronic primary insomnia by means of heart rate variability (HRV) analysis. Eighty-five consecutive patients affected by chronic primary insomnia were enrolled (38 men and 47 women; mean age: 53.2 ± 13.6). Patients were compared with a control group composed of 55 healthy participants matched for age and gender (23 men and 32 women; mean age: 54.2 ± 13.9). Patients underwent an insomnia study protocol that included subjective sleep evaluation, psychometric measures, and home-based polysomnography with evaluation of HRV in wake before sleep, in all sleep stages, and in wake after final awakening. Patients showed modifications of heart rate and HRV parameters, consistent with increased sympathetic activity, while awake before sleep and during Stage-2 non-REM sleep. No significant differences between insomniacs and controls could be detected during slow-wave sleep, REM sleep, and post-sleep wake. These results are consistent with the hypothesis that autonomic hyper-arousal is a major pathogenic mechanism in primary insomnia, and confirm that this condition is associated with an increased cardiovascular risk.

Farina, B., Dittoni, S., Colicchio, S., Testani, E., Losurdo, A., Gnoni, V., Di Blasi, C., Brunetti, R., Contardi, A., Mazza, S., Della Marca, G., Heart rate and heart rate variability modification in chronic insomnia patients, <<BEHAVIORAL SLEEP MEDICINE>>, 2014; 12 (4): 290-306. [doi:10.1080/15402002.2013.801346] [http://hdl.handle.net/10807/58131]

Heart rate and heart rate variability modification in chronic insomnia patients

Dittoni, Serena;Colicchio, Salvatore;Testani, Elisa;Losurdo, Anna;Gnoni, Valentina;Di Blasi, Chiara;Mazza, Salvatore;Della Marca, Giacomo
2014

Abstract

Chronic insomnia is highly prevalent in the general population, provoking personal distress and increased risk for psychiatric and medical disorders. Autonomic hyper-arousal could be a pathogenic mechanism of chronic primary insomnia. The aim of this study was to investigate autonomic activity in patients with chronic primary insomnia by means of heart rate variability (HRV) analysis. Eighty-five consecutive patients affected by chronic primary insomnia were enrolled (38 men and 47 women; mean age: 53.2 ± 13.6). Patients were compared with a control group composed of 55 healthy participants matched for age and gender (23 men and 32 women; mean age: 54.2 ± 13.9). Patients underwent an insomnia study protocol that included subjective sleep evaluation, psychometric measures, and home-based polysomnography with evaluation of HRV in wake before sleep, in all sleep stages, and in wake after final awakening. Patients showed modifications of heart rate and HRV parameters, consistent with increased sympathetic activity, while awake before sleep and during Stage-2 non-REM sleep. No significant differences between insomniacs and controls could be detected during slow-wave sleep, REM sleep, and post-sleep wake. These results are consistent with the hypothesis that autonomic hyper-arousal is a major pathogenic mechanism in primary insomnia, and confirm that this condition is associated with an increased cardiovascular risk.
Inglese
Farina, B., Dittoni, S., Colicchio, S., Testani, E., Losurdo, A., Gnoni, V., Di Blasi, C., Brunetti, R., Contardi, A., Mazza, S., Della Marca, G., Heart rate and heart rate variability modification in chronic insomnia patients, <>, 2014; 12 (4): 290-306. [doi:10.1080/15402002.2013.801346] [http://hdl.handle.net/10807/58131]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/58131
Citazioni
  • ???jsp.display-item.citation.pmc??? 19
  • Scopus 46
  • ???jsp.display-item.citation.isi??? 43
social impact