The CDKN2A locus on human chromosome 9p21 encodes two proteins named p16INK4a and p14ARF, known to function as tumour suppressors via the retinoblastoma (Rb) or the p53 pathway. The p53 tumour suppressor gene is the most commonly mutated gene in human and mouse cancers. Disruption of the p53 and Rb pathways is a fundamental trend of most human cancer cells. Recent studies have shown that the CDKN2A gene plays an active role in the p53 and Rb tumour suppressor pathways. Genetic abnormalities in CDKN2A have been well documented in human melanoma, but their involvement in nonmelanoma skin cancer (NMSC) is less clear.
Pacifico, A., Goldberg, L., Peris, K., Chimenti, S., Leone, G., Ananthaswamy, H., Loss of CDKN2A and p14ARF expression occurs frequently in human nonmelanoma skin cancers, <<BRITISH JOURNAL OF DERMATOLOGY>>, 2008; 158 (2): 291-297. [doi:10.1111/j.1365-2133.2007.08360.x] [http://hdl.handle.net/10807/57532]