Background: Endothelial dysfunction, reduced coronary flow reserve and increased markers of inflammation are detectable in cardiac syndrome X (CSX). In this study we investigated the relation between inflammation and systemic endothelial function in CSX patients. Methods: We studied 42 CSX patients (55±6 years, 14 men) and 20 healthy subjects (52±7 years, 9 men). Systemic endothelial function was assessed by flow-mediated dilation (FMD) of the brachial artery after 5-minute of forearm cuff inflation. Serum C-reactive protein (CRP) was measured by a high-sensitivity method. Results: FMD was significantly lower in CSX patients compared to controls (4.8±4.4 vs. 13.7±4%, p<0.001), whereas CRP levels were higher in CSX patients than in controls (2.7±2.4 vs. 0.7±0.4 mg/L, p=0.001). In CSX patients FMD showed a significant inverse correlation with CRP levels, even after adjustment for potentially confounding variables (r=-0.34, p=0.006). Conclusion: An impaired FMD is detectable in CSX patients, suggesting a generalized abnormality in vascular function. Subclinical inflammation seems to play a significant role in the impairment of endothelium-dependent vasodilator function of these patients.

Tondi, P., Santoliquido, A., Di Giorgio, A., Sestito, A., Sgueglia, G. A., Flore, R. A., Careri, G., Pinnacchio, G., Lanza, G. A., Crea, F., Endothelial dysfunction as assessed by flow-mediated dilation in patients with cardiac syndrome X: role of inflammation, <<EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES>>, 2011; 2011 (Settembre): 1074-1077 [http://hdl.handle.net/10807/5709]

Endothelial dysfunction as assessed by flow-mediated dilation in patients with cardiac syndrome X: role of inflammation

Tondi, Paolo;Santoliquido, Angelo;Di Giorgio, Andrea;Sestito, Alfonso;Sgueglia, Gregory Angelo;Flore, Roberto Antonio;Careri, Giulia;Lanza, Gaetano Antonio;Crea, Filippo
2011

Abstract

Background: Endothelial dysfunction, reduced coronary flow reserve and increased markers of inflammation are detectable in cardiac syndrome X (CSX). In this study we investigated the relation between inflammation and systemic endothelial function in CSX patients. Methods: We studied 42 CSX patients (55±6 years, 14 men) and 20 healthy subjects (52±7 years, 9 men). Systemic endothelial function was assessed by flow-mediated dilation (FMD) of the brachial artery after 5-minute of forearm cuff inflation. Serum C-reactive protein (CRP) was measured by a high-sensitivity method. Results: FMD was significantly lower in CSX patients compared to controls (4.8±4.4 vs. 13.7±4%, p<0.001), whereas CRP levels were higher in CSX patients than in controls (2.7±2.4 vs. 0.7±0.4 mg/L, p=0.001). In CSX patients FMD showed a significant inverse correlation with CRP levels, even after adjustment for potentially confounding variables (r=-0.34, p=0.006). Conclusion: An impaired FMD is detectable in CSX patients, suggesting a generalized abnormality in vascular function. Subclinical inflammation seems to play a significant role in the impairment of endothelium-dependent vasodilator function of these patients.
Inglese
Tondi, P., Santoliquido, A., Di Giorgio, A., Sestito, A., Sgueglia, G. A., Flore, R. A., Careri, G., Pinnacchio, G., Lanza, G. A., Crea, F., Endothelial dysfunction as assessed by flow-mediated dilation in patients with cardiac syndrome X: role of inflammation, <<EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES>>, 2011; 2011 (Settembre): 1074-1077 [http://hdl.handle.net/10807/5709]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/5709
Citazioni
  • ???jsp.display-item.citation.pmc??? 8
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact