Concomitant primary cutaneous melanoma in monozygotic twins has been reported in only two pairs but in neither of them genetic analysis was performed. Two high-penetrance susceptibility genes, CDKN2A and CDK4 and one low-penetrance gene, MC1R, are well-defined genetic risk factors for melanoma. MITF has been recently identified as a novel intermediate risk melanoma-predisposing gene.
Pellegrini, C., Fargnoli, M., Suppa, M., Peris, K., MC1R variants predisposing to concomitant primary cutaneous melanoma in a monozygotic twin pair, <<BMC MEDICAL GENETICS>>, 2012; 13 (Settembre): 81-81. [doi:10.1186/1471-2350-13-81] [http://hdl.handle.net/10807/56394]
MC1R variants predisposing to concomitant primary cutaneous melanoma in a monozygotic twin pair
Peris, Ketty
2012
Abstract
Concomitant primary cutaneous melanoma in monozygotic twins has been reported in only two pairs but in neither of them genetic analysis was performed. Two high-penetrance susceptibility genes, CDKN2A and CDK4 and one low-penetrance gene, MC1R, are well-defined genetic risk factors for melanoma. MITF has been recently identified as a novel intermediate risk melanoma-predisposing gene.
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