The expression of the proto-oncogene c-myc was studied in tumorous skin lesions of (cutaneous) lymphoproliferative diseases (3 cases of pseudolymphoma, 8 cases of non-Hodgkin lymphoma and 1 case of lymph node involvement in mycosis fungoides) in a total of 12 patients. c-myc mRNA levels were quantified by Northern blot analysis followed by densitometric evaluation of the specific bands. Higher levels of c-myc mRNA expression were observed in lymphomas as compared with pseudolymphomas (p greater than 0.05). No significant differences in c-myc mRNA values were detected between B and T cell pseudolymphomas. Our results suggest that c-myc mRNA overexpression is associated with malignant lymphomas of the skin. We conclude that the measurement of c-myc mRNA levels may contribute to further characterize cutaneous lymphoproliferative diseases.

Peris, K., Cerroni, L., Kerl, H., Radaszkiewicz, T., Chimenti, S., Höfler, H., Expression of c-myc in cutaneous lymphomas and pseudolymphomas, <<DERMATOLOGICA>>, 1991; 183 (1): 1-6 [http://hdl.handle.net/10807/56178]

Expression of c-myc in cutaneous lymphomas and pseudolymphomas

Peris, Ketty;
1991

Abstract

The expression of the proto-oncogene c-myc was studied in tumorous skin lesions of (cutaneous) lymphoproliferative diseases (3 cases of pseudolymphoma, 8 cases of non-Hodgkin lymphoma and 1 case of lymph node involvement in mycosis fungoides) in a total of 12 patients. c-myc mRNA levels were quantified by Northern blot analysis followed by densitometric evaluation of the specific bands. Higher levels of c-myc mRNA expression were observed in lymphomas as compared with pseudolymphomas (p greater than 0.05). No significant differences in c-myc mRNA values were detected between B and T cell pseudolymphomas. Our results suggest that c-myc mRNA overexpression is associated with malignant lymphomas of the skin. We conclude that the measurement of c-myc mRNA levels may contribute to further characterize cutaneous lymphoproliferative diseases.
Inglese
Peris, K., Cerroni, L., Kerl, H., Radaszkiewicz, T., Chimenti, S., Höfler, H., Expression of c-myc in cutaneous lymphomas and pseudolymphomas, <>, 1991; 183 (1): 1-6 [http://hdl.handle.net/10807/56178]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/56178
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