INTRODUCTION: The 2004 version of the World Health Organization classification subdivides thymic epithelial tumors into A, AB, B1, B2, and B3 (and rare other) thymomas and thymic carcinomas (TC). Due to a morphological continuum between some thymoma subtypes and some morphological overlap between thymomas and TC, a variable proportion of cases may pose problems in classification, contributing to the poor interobserver reproducibility in some studies.METHODS: To overcome this problem, hematoxylin-eosin-stained and immunohistochemically processed sections of prototypic, "borderland," and "combined" thymomas and TC (n = 72) were studied by 18 pathologists at an international consensus slide workshop supported by the International Thymic Malignancy Interest Group.RESULTS: Consensus was achieved on refined criteria for decision making at the A/AB borderland, the distinction between B1, B2, and B3 thymomas and the separation of B3 thymomas from TCs. "Atypical type A thymoma" is tentatively proposed as a new type A thymoma variant. New reporting strategies for tumors with more than one histological pattern are proposed.CONCLUSION: These guidelines can set the stage for reproducibility studies and the design of a clinically meaningful grading system for thymic epithelial tumors.

Marx, A., Strobel, P., Badve, S., Chalabreysse, L., Chan, J., Chen, G., De Leval, L., Detterbeck, F., Girard, N., Huang, J., Kurrer, M., Lauriola, L., Marino, M., Matsuno, Y., Molina, T., Mukai, K., Nicholson, A., Nonaka, D., Rieker, R., Rosai, J., Ruffini, E., Travis, W., ITMIG Consensus Statement on the Use of the WHO Histological Classification of Thymoma and Thymic Carcinoma: Refined Definitions, Histological Criteria, and Reporting, <<JOURNAL OF THORACIC ONCOLOGY>>, 2014; 9 (5): 596-611. [doi:10.1097/JTO.0000000000000154] [http://hdl.handle.net/10807/55872]

ITMIG Consensus Statement on the Use of the WHO Histological Classification of Thymoma and Thymic Carcinoma: Refined Definitions, Histological Criteria, and Reporting

Lauriola, Libero;
2014

Abstract

INTRODUCTION: The 2004 version of the World Health Organization classification subdivides thymic epithelial tumors into A, AB, B1, B2, and B3 (and rare other) thymomas and thymic carcinomas (TC). Due to a morphological continuum between some thymoma subtypes and some morphological overlap between thymomas and TC, a variable proportion of cases may pose problems in classification, contributing to the poor interobserver reproducibility in some studies.METHODS: To overcome this problem, hematoxylin-eosin-stained and immunohistochemically processed sections of prototypic, "borderland," and "combined" thymomas and TC (n = 72) were studied by 18 pathologists at an international consensus slide workshop supported by the International Thymic Malignancy Interest Group.RESULTS: Consensus was achieved on refined criteria for decision making at the A/AB borderland, the distinction between B1, B2, and B3 thymomas and the separation of B3 thymomas from TCs. "Atypical type A thymoma" is tentatively proposed as a new type A thymoma variant. New reporting strategies for tumors with more than one histological pattern are proposed.CONCLUSION: These guidelines can set the stage for reproducibility studies and the design of a clinically meaningful grading system for thymic epithelial tumors.
2014
Inglese
Marx, A., Strobel, P., Badve, S., Chalabreysse, L., Chan, J., Chen, G., De Leval, L., Detterbeck, F., Girard, N., Huang, J., Kurrer, M., Lauriola, L., Marino, M., Matsuno, Y., Molina, T., Mukai, K., Nicholson, A., Nonaka, D., Rieker, R., Rosai, J., Ruffini, E., Travis, W., ITMIG Consensus Statement on the Use of the WHO Histological Classification of Thymoma and Thymic Carcinoma: Refined Definitions, Histological Criteria, and Reporting, <<JOURNAL OF THORACIC ONCOLOGY>>, 2014; 9 (5): 596-611. [doi:10.1097/JTO.0000000000000154] [http://hdl.handle.net/10807/55872]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/55872
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 242
  • ???jsp.display-item.citation.isi??? 207
social impact