In this study we used an immunocytochemical approach to study nestin expression in the rat hippocampus during trimethyltin-induced neurodegeneration at different time points (5, 10, 15, 21 and 50 days) after intoxication. Nestin is transiently expressed by a subpopulation of astroglial cells strictly associated with pyramidal neurons in those hippocampal areas severely affected by degeneration. This observation shows that cerebral tissue re-expresses this developmental protein during neurodegenerative diseases in early stages of astroglial activation.
Geloso, M. C., Corvino, V., Cavallo, V., Toesca Di Castellazzo, A., Guadagni, E., Passalacqua, R., Michetti, F., Expression of astrocytic nestin in the rat hippocampus during trimethyltin-induced neurodegeneration, <<NEUROSCIENCE LETTERS>>, 2004; (357): 103-106 [http://hdl.handle.net/10807/5429]
Expression of astrocytic nestin in the rat hippocampus during trimethyltin-induced neurodegeneration
Geloso, Maria Concetta;Corvino, Valentina;Cavallo, Valentina;Toesca Di Castellazzo, Amelia;Guadagni, Enrico;Passalacqua, Roberto;Michetti, Fabrizio
2004
Abstract
In this study we used an immunocytochemical approach to study nestin expression in the rat hippocampus during trimethyltin-induced neurodegeneration at different time points (5, 10, 15, 21 and 50 days) after intoxication. Nestin is transiently expressed by a subpopulation of astroglial cells strictly associated with pyramidal neurons in those hippocampal areas severely affected by degeneration. This observation shows that cerebral tissue re-expresses this developmental protein during neurodegenerative diseases in early stages of astroglial activation.
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