Superinfection with drug resistant HIV strains could potentially contribute to compromised therapy in patients initially infected with drug-sensitive virus and receiving antiretroviral therapy. To investigate the importance of this potential route to drug resistance, we developed a bioinformatics pipeline to detect superinfection from routinely collected genotyping data, and assessed whether superinfection contributed to increased drug resistance in a large European cohort of viremic, drug treated patients.

Bartha, I., Assel, M., Sloot, P., Zazzi, M., Torti, C., Schülter, E., De Luca, A., Sönnerborg, A., Abecasis, A., Van Laethem, K., Rosi, A., Svärd, J., Paredes, R., Van De Vijver, D., Vandamme, A., Müller, V., Superinfection with drug-resistant HIV is rare and does not contribute substantially to therapy failure in a large European cohort, <<BMC INFECTIOUS DISEASES>>, 2013; 13 (Novembre): 537-537. [doi:10.1186/1471-2334-13-537] [http://hdl.handle.net/10807/54171]

Superinfection with drug-resistant HIV is rare and does not contribute substantially to therapy failure in a large European cohort

De Luca, Andrea;
2013

Abstract

Superinfection with drug resistant HIV strains could potentially contribute to compromised therapy in patients initially infected with drug-sensitive virus and receiving antiretroviral therapy. To investigate the importance of this potential route to drug resistance, we developed a bioinformatics pipeline to detect superinfection from routinely collected genotyping data, and assessed whether superinfection contributed to increased drug resistance in a large European cohort of viremic, drug treated patients.
2013
Inglese
Bartha, I., Assel, M., Sloot, P., Zazzi, M., Torti, C., Schülter, E., De Luca, A., Sönnerborg, A., Abecasis, A., Van Laethem, K., Rosi, A., Svärd, J., Paredes, R., Van De Vijver, D., Vandamme, A., Müller, V., Superinfection with drug-resistant HIV is rare and does not contribute substantially to therapy failure in a large European cohort, <<BMC INFECTIOUS DISEASES>>, 2013; 13 (Novembre): 537-537. [doi:10.1186/1471-2334-13-537] [http://hdl.handle.net/10807/54171]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/54171
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