Superinfection with drug resistant HIV strains could potentially contribute to compromised therapy in patients initially infected with drug-sensitive virus and receiving antiretroviral therapy. To investigate the importance of this potential route to drug resistance, we developed a bioinformatics pipeline to detect superinfection from routinely collected genotyping data, and assessed whether superinfection contributed to increased drug resistance in a large European cohort of viremic, drug treated patients.
Bartha, I., Assel, M., Sloot, P., Zazzi, M., Torti, C., Schülter, E., De Luca, A., Sönnerborg, A., Abecasis, A., Van Laethem, K., Rosi, A., Svärd, J., Paredes, R., Van De Vijver, D., Vandamme, A., Müller, V., Superinfection with drug-resistant HIV is rare and does not contribute substantially to therapy failure in a large European cohort, <<BMC INFECTIOUS DISEASES>>, 2013; 13 (Novembre): 537-537. [doi:10.1186/1471-2334-13-537] [http://hdl.handle.net/10807/54171]
Superinfection with drug-resistant HIV is rare and does not contribute substantially to therapy failure in a large European cohort
Torti, Carlo;De Luca, Andrea;
2013
Abstract
Superinfection with drug resistant HIV strains could potentially contribute to compromised therapy in patients initially infected with drug-sensitive virus and receiving antiretroviral therapy. To investigate the importance of this potential route to drug resistance, we developed a bioinformatics pipeline to detect superinfection from routinely collected genotyping data, and assessed whether superinfection contributed to increased drug resistance in a large European cohort of viremic, drug treated patients.
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