Objective The study aimed to determine the utility of single-fibre electromyography (SFEMG) in the diagnosis of myasthenia gravis (MG) in subjects with a clinical suspicion of the disease. Methods We performed a prospective, single-blinded study on 100 consecutive patients. SFEMG was not considered a criterion in making the MG diagnosis. For all cases, a different physician than the one performing SFEMG made the diagnosis of MG. All subjects underwent standard SFEMG of a single muscle, the orbicularis oculi. Results SFEMG was abnormal in 67 of 100 patients. A final diagnosis of definite MG was made in 54 patients (30 men/24 women). SFEMG was positive in 53 of 54 patients diagnosed with MG. The sensitivity of SFEMG in diagnosing MG was 98% (95% CI: 0.94–1.02), while the specificity was 70% (95% CI: 0.54–0.86), with a positive predictive value of 79% (95% CI: 0.74–0.79) and a negative predictive value of 97% (95% CI: 0.94–0.99). Conclusions In this cohort of patients, normal SFEMG findings were unlikely to occur in patients with MG.

Padua, L., Caliandro, P., Di Iasi, G., Pazzaglia, C., Ciaraffa, F., Evoli, A., Reliability of SFEMG in diagnosing myasthenia gravis: Sensitivity and specificity calculated on 100 prospective cases., <<CLINICAL NEUROPHYSIOLOGY>>, 2013; (Novembre): N/A-N/A. [doi:10.1016/j.clinph.2013.11.005] [http://hdl.handle.net/10807/54083]

Reliability of SFEMG in diagnosing myasthenia gravis: Sensitivity and specificity calculated on 100 prospective cases.

Padua, Luca;Caliandro, Pietro;Pazzaglia, Costanza;Ciaraffa, Francesca;Evoli, Amelia
2013

Abstract

Objective The study aimed to determine the utility of single-fibre electromyography (SFEMG) in the diagnosis of myasthenia gravis (MG) in subjects with a clinical suspicion of the disease. Methods We performed a prospective, single-blinded study on 100 consecutive patients. SFEMG was not considered a criterion in making the MG diagnosis. For all cases, a different physician than the one performing SFEMG made the diagnosis of MG. All subjects underwent standard SFEMG of a single muscle, the orbicularis oculi. Results SFEMG was abnormal in 67 of 100 patients. A final diagnosis of definite MG was made in 54 patients (30 men/24 women). SFEMG was positive in 53 of 54 patients diagnosed with MG. The sensitivity of SFEMG in diagnosing MG was 98% (95% CI: 0.94–1.02), while the specificity was 70% (95% CI: 0.54–0.86), with a positive predictive value of 79% (95% CI: 0.74–0.79) and a negative predictive value of 97% (95% CI: 0.94–0.99). Conclusions In this cohort of patients, normal SFEMG findings were unlikely to occur in patients with MG.
2013
Inglese
Padua, L., Caliandro, P., Di Iasi, G., Pazzaglia, C., Ciaraffa, F., Evoli, A., Reliability of SFEMG in diagnosing myasthenia gravis: Sensitivity and specificity calculated on 100 prospective cases., <<CLINICAL NEUROPHYSIOLOGY>>, 2013; (Novembre): N/A-N/A. [doi:10.1016/j.clinph.2013.11.005] [http://hdl.handle.net/10807/54083]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/54083
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