To evaluate whether iron and copper levels in serum, plasma, and cerebrospinal fluid are disarranged in Parkinson's disease (PD), we performed meta-analyses of 33 studies on the topic published from 1987 to 2011 and contextually carried out a replication study in serum by ourselves as well. We found no variation in metals between PD patients and healthy controls, according to our replication study. The metaregression for sex revealed that serum copper differences found in some studies could be referred to the different percentage of women in the PD sample. Transferrin and transferrin saturation levels found increased in PD subjects underline the concept to extend the iron study in PD to iron master proteins.

Mariani, S., Ventriglia, M., Simonelli, I., Donno, S., Bucossi, S., Vernieri, F., Melgari, J., Pasqualetti, P., Rossini, P. M., Squitti, R., Fe and Cu do not differ in Parkinson's disease: a replication study plus meta-analysis, <<NEUROBIOLOGY OF AGING>>, 2013; 34 (2): 632-633. [doi:10.1016/j.neurobiolaging.2012.05.015] [http://hdl.handle.net/10807/54069]

Fe and Cu do not differ in Parkinson's disease: a replication study plus meta-analysis

Rossini, Paolo Maria;
2013

Abstract

To evaluate whether iron and copper levels in serum, plasma, and cerebrospinal fluid are disarranged in Parkinson's disease (PD), we performed meta-analyses of 33 studies on the topic published from 1987 to 2011 and contextually carried out a replication study in serum by ourselves as well. We found no variation in metals between PD patients and healthy controls, according to our replication study. The metaregression for sex revealed that serum copper differences found in some studies could be referred to the different percentage of women in the PD sample. Transferrin and transferrin saturation levels found increased in PD subjects underline the concept to extend the iron study in PD to iron master proteins.
2013
Inglese
Mariani, S., Ventriglia, M., Simonelli, I., Donno, S., Bucossi, S., Vernieri, F., Melgari, J., Pasqualetti, P., Rossini, P. M., Squitti, R., Fe and Cu do not differ in Parkinson's disease: a replication study plus meta-analysis, <<NEUROBIOLOGY OF AGING>>, 2013; 34 (2): 632-633. [doi:10.1016/j.neurobiolaging.2012.05.015] [http://hdl.handle.net/10807/54069]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/54069
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