Patients with high-grade glioma (HGG) still have a very poor prognosis. The infiltrative nature of the tumor and the inter- and intra-tumoral cellular and genetic heterogeneity, leading to the acquisition of new mutations over time, represent the main causes of treatment failure. Radioimmunotherapy represents an emerging approach for the treatment of HGG. Radioimmunotherapy utilizes a molecular vehicle (monoclonal antibodies) to deliver a radionuclide (the drug) to a selected cell population target. This review will provide an overview of preclinical and clinical studies to date and assess the effectiveness of radioimmunotherapy, focusing on possible future therapies for the treatment of HGG.

De Bonis, P., Lofrese, G., Anile, C., Pompucci, A., Vigo, V., Mangiola, A., Radioimmunotherapy for high-grade glioma, <<IMMUNOTHERAPY>>, 2013; 5 (6): 647-659. [doi:10.2217/imt.13.43] [http://hdl.handle.net/10807/53881]

Radioimmunotherapy for high-grade glioma

De Bonis, Pasquale;Lofrese, Giorgio;Anile, Carmelo;Pompucci, Angelo;Vigo, Vera;Mangiola, Annunziato
2013

Abstract

Patients with high-grade glioma (HGG) still have a very poor prognosis. The infiltrative nature of the tumor and the inter- and intra-tumoral cellular and genetic heterogeneity, leading to the acquisition of new mutations over time, represent the main causes of treatment failure. Radioimmunotherapy represents an emerging approach for the treatment of HGG. Radioimmunotherapy utilizes a molecular vehicle (monoclonal antibodies) to deliver a radionuclide (the drug) to a selected cell population target. This review will provide an overview of preclinical and clinical studies to date and assess the effectiveness of radioimmunotherapy, focusing on possible future therapies for the treatment of HGG.
Inglese
De Bonis, P., Lofrese, G., Anile, C., Pompucci, A., Vigo, V., Mangiola, A., Radioimmunotherapy for high-grade glioma, <>, 2013; 5 (6): 647-659. [doi:10.2217/imt.13.43] [http://hdl.handle.net/10807/53881]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/53881
Citazioni
  • ???jsp.display-item.citation.pmc??? 4
  • Scopus 13
  • ???jsp.display-item.citation.isi??? 11
social impact