Several volatile organic compounds have been identified in exhaled breath in healthy subjects and patients with respiratory diseases by gas chromatography/mass spectrometry. Identification of selective patterns of volatile organic compounds in exhaled breath could be used as a biomarker of inflammatory lung diseases. An electronic nose (e-nose) is an artificial sensor system that generally consists of an array of chemical sensors for detection of volatile organic compound profiles (breathprints) and an algorithm for pattern recognition. E-noses are handheld, portable devices that provide immediate results. E-noses discriminate between patients with respiratory disease, including asthma, COPD and lung cancer, and healthy control subjects, and also among patients with different respiratory diseases. E-nose breathprints are associated with airway inflammation activity. In combination with other 'omics' platforms, e-nose technology might contribute to the identification of new surrogate markers of pulmonary inflammation and subphenotypes of patients with respiratory diseases, provide a molecular basis to a personalized pharmacological treatment, and facilitate the development of new drugs.

Montuschi, P., Mores, N., Trové, A., Mondino, C., Barnes, P. J., The electronic nose in respiratory medicine., <<RESPIRATION>>, 2013; 85 (Gennaio): 72-84. [doi:10.1159/000340044] [http://hdl.handle.net/10807/53724]

The electronic nose in respiratory medicine.

Montuschi, Paolo;Mores, Nadia;
2013

Abstract

Several volatile organic compounds have been identified in exhaled breath in healthy subjects and patients with respiratory diseases by gas chromatography/mass spectrometry. Identification of selective patterns of volatile organic compounds in exhaled breath could be used as a biomarker of inflammatory lung diseases. An electronic nose (e-nose) is an artificial sensor system that generally consists of an array of chemical sensors for detection of volatile organic compound profiles (breathprints) and an algorithm for pattern recognition. E-noses are handheld, portable devices that provide immediate results. E-noses discriminate between patients with respiratory disease, including asthma, COPD and lung cancer, and healthy control subjects, and also among patients with different respiratory diseases. E-nose breathprints are associated with airway inflammation activity. In combination with other 'omics' platforms, e-nose technology might contribute to the identification of new surrogate markers of pulmonary inflammation and subphenotypes of patients with respiratory diseases, provide a molecular basis to a personalized pharmacological treatment, and facilitate the development of new drugs.
2013
Inglese
Montuschi, P., Mores, N., Trové, A., Mondino, C., Barnes, P. J., The electronic nose in respiratory medicine., <<RESPIRATION>>, 2013; 85 (Gennaio): 72-84. [doi:10.1159/000340044] [http://hdl.handle.net/10807/53724]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/53724
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