Hypersensitivity reactions (HSRs) may occur in children with cancer during the use of almost all chemotherapeutic drugs. HSRs may also produce a negative impact on treatment intensity and, as a consequence, worsen patients' outcome. The aim of this review is to summarize the incidence and the clinical features of HSRs occurring in children with cancer treated with chemotherapeutic drugs and their impact on treatment efficacy, in order to outline possible adequate prevention and management strategies.
Ruggiero, A., Triarico, S., Trombatore, G., Battista, A., Dell'Acqua, F., Rizzari, C., Riccardi, R., Incidence, clinical features and management of hypersensitivity reactions to chemotherapeutic drugs in children with cancer, <<EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY>>, 2013; 69 (10): 1739-1746. [doi:10.1007/s00228-013-1546-0] [http://hdl.handle.net/10807/53456]
Incidence, clinical features and management of hypersensitivity reactions to chemotherapeutic drugs in children with cancer
Ruggiero, Antonio;Triarico, Silvia;Trombatore, Giovanna;Battista, Andrea;Riccardi, Riccardo
2013
Abstract
Hypersensitivity reactions (HSRs) may occur in children with cancer during the use of almost all chemotherapeutic drugs. HSRs may also produce a negative impact on treatment intensity and, as a consequence, worsen patients' outcome. The aim of this review is to summarize the incidence and the clinical features of HSRs occurring in children with cancer treated with chemotherapeutic drugs and their impact on treatment efficacy, in order to outline possible adequate prevention and management strategies.
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