The increasing frequency of ventilator-associated pneumonia (VAP) caused by colistin-only susceptible (COS) gram-negative bacteria (GNB) is of great concern. Adjunctive aerosolized (AS) colistin can reportedly increase alveolar levels of the drug without increasing systemic toxicity. Good clinical results have been obtained in patients with cystic fibrosis, but conflicting data have been reported in patients with VAP.

Tumbarello, M., De Pascale, G., Trecarichi, E., De Martino, S., Bello, G., Maviglia, R., Spanu, T., Antonelli, M., Effect of aerosolized colistin as adjunctive treatment on the outcomes of microbiologically documented ventilator-associated pneumonia caused by colistin-only susceptible gram-negative bacteria, <<CHEST>>, 2013; 144 (6): 1768-1775. [doi:10.1378/chest.13-1018] [http://hdl.handle.net/10807/53443]

Effect of aerosolized colistin as adjunctive treatment on the outcomes of microbiologically documented ventilator-associated pneumonia caused by colistin-only susceptible gram-negative bacteria

Tumbarello, Mario;De Pascale, G;Spanu, Teresa;Antonelli, Massimo
2013

Abstract

The increasing frequency of ventilator-associated pneumonia (VAP) caused by colistin-only susceptible (COS) gram-negative bacteria (GNB) is of great concern. Adjunctive aerosolized (AS) colistin can reportedly increase alveolar levels of the drug without increasing systemic toxicity. Good clinical results have been obtained in patients with cystic fibrosis, but conflicting data have been reported in patients with VAP.
2013
Inglese
Tumbarello, M., De Pascale, G., Trecarichi, E., De Martino, S., Bello, G., Maviglia, R., Spanu, T., Antonelli, M., Effect of aerosolized colistin as adjunctive treatment on the outcomes of microbiologically documented ventilator-associated pneumonia caused by colistin-only susceptible gram-negative bacteria, <<CHEST>>, 2013; 144 (6): 1768-1775. [doi:10.1378/chest.13-1018] [http://hdl.handle.net/10807/53443]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10807/53443
Citazioni
  • ???jsp.display-item.citation.pmc??? 40
  • Scopus 121
  • ???jsp.display-item.citation.isi??? 112
social impact