Among treatments proposed for idiopathic male infertility, antiestrogens, like tamoxifen, play a possible role. On the other hand, oxidative stress is a mechanism well recognized for deleterious effects on spermatozoa function. After reviewing the literature on the effects of estrogens in modulation of antioxidant systems, in both sexes, and in different in vivo and in vitro models, we suggest, also on the basis of personal data, that a tamoxifen treatment could be active via an increase in seminal antioxidants.
Mancini, A., Raimondo, S., Persano, M., Di Segni, C., Cammarano, M., Gadotti, G., Silvestrini, A., Pontecorvi, A., Meucci Calabrese, E., Estrogens as Antioxidant Modulators in Human Fertility, <<INTERNATIONAL JOURNAL OF ENDOCRINOLOGY>>, 2013; 2013 (Novembre): 607939-607939. [doi:10.1155/2013/607939] [http://hdl.handle.net/10807/52812]
Estrogens as Antioxidant Modulators in Human Fertility
Mancini, Antonio;Raimondo, Sebastiano;Silvestrini, Andrea;Pontecorvi, Alfredo;Meucci Calabrese, Elisabetta
2013
Abstract
Among treatments proposed for idiopathic male infertility, antiestrogens, like tamoxifen, play a possible role. On the other hand, oxidative stress is a mechanism well recognized for deleterious effects on spermatozoa function. After reviewing the literature on the effects of estrogens in modulation of antioxidant systems, in both sexes, and in different in vivo and in vitro models, we suggest, also on the basis of personal data, that a tamoxifen treatment could be active via an increase in seminal antioxidants.
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