Diabetes mellitus (DM) is a pandemics that affects more than 170 million people worldwide, associated with increased mortality and morbidity due to coronary artery disease (CAD). In type 1 (T1) DM, the main pathogenic mechanism seems to be the destruction of pancreatic β -cells mediated by autoreactive T-cells resulting in chronic insulitis, while in type 2 (T2) DM primary insulin resistance, rather than defective insulin production due to β -cell destruction, seems to be the triggering alteration. In our study, we investigated the role of systemic inflammation and T-cell subsets in T1- and T2DM and the possible mechanisms underlying the increased cardiovascular risk associated with these diseases.

Pedicino, D., Liuzzo, G., Trotta, F., Giglio, A. F., Giubilato, S., Martini, F., Zaccardi, F., Scavone, G., Previtero, M., Massaro, G., Cialdella, P., Cardillo, M. T., Pitocco, D., Ghirlanda, G., Crea, F., Adaptive immunity, inflammation, and cardiovascular complications in type 1 and type 2 diabetes mellitus, <<JOURNAL OF DIABETES RESEARCH>>, 2013; 2013 (Maggio): N/A-N/A. [doi:10.1155/2013/184258] [http://hdl.handle.net/10807/52657]

Adaptive immunity, inflammation, and cardiovascular complications in type 1 and type 2 diabetes mellitus

Pedicino, Daniela;Liuzzo, Giovanna;Trotta, Francesco;Giglio, Ada Francesca;Giubilato, Simona;Martini, Francesca;Zaccardi, Francesco;Scavone, Giuseppe;Cialdella, Pio;Cardillo, Maria Teresa;Pitocco, Dario;Ghirlanda, Giovanni;Crea, Filippo
2013

Abstract

Diabetes mellitus (DM) is a pandemics that affects more than 170 million people worldwide, associated with increased mortality and morbidity due to coronary artery disease (CAD). In type 1 (T1) DM, the main pathogenic mechanism seems to be the destruction of pancreatic β -cells mediated by autoreactive T-cells resulting in chronic insulitis, while in type 2 (T2) DM primary insulin resistance, rather than defective insulin production due to β -cell destruction, seems to be the triggering alteration. In our study, we investigated the role of systemic inflammation and T-cell subsets in T1- and T2DM and the possible mechanisms underlying the increased cardiovascular risk associated with these diseases.
Inglese
Pedicino, D., Liuzzo, G., Trotta, F., Giglio, A. F., Giubilato, S., Martini, F., Zaccardi, F., Scavone, G., Previtero, M., Massaro, G., Cialdella, P., Cardillo, M. T., Pitocco, D., Ghirlanda, G., Crea, F., Adaptive immunity, inflammation, and cardiovascular complications in type 1 and type 2 diabetes mellitus, <>, 2013; 2013 (Maggio): N/A-N/A. [doi:10.1155/2013/184258] [http://hdl.handle.net/10807/52657]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/10807/52657
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