Frequent blood loss induces progressive depletion of iron stores, leading to iron deficiency and, ultimately, to overt iron-deficient anaemia. The erythropoietin-mediated bone marrow response to anaemia is under the control of hypoxia-inducible factors (HIF), the master regulators of oxygen and iron homeostasis. Since the HIF-1α(Pro-582-Ser) variant is associated with elevated trans-activation capacity of hypoxia responsive elements of target genes, we investigated whether the HIF-1α(Pro-582-Ser) polymorphism might influence the response to repeated blood withdrawals.
Torti, L., Teofili, L., Capodimonti, S., Nuzzolo, E. R., Iachininoto, M. G., Massini, G., Coluzzi, S., Tafuri, A., Fiorin, F., Girelli, G., Zini Tanzi, G., Larocca, L. M., Hypoxia-inducible factor-1α(Pro-582-Ser) polymorphism prevents iron deprivation in healthy blood donors, <<BLOOD TRANSFUSION>>, 2013; 11 (4): 553-557. [doi:10.2450/2013.0076-13] [http://hdl.handle.net/10807/52315]
Hypoxia-inducible factor-1α(Pro-582-Ser) polymorphism prevents iron deprivation in healthy blood donors
Torti, Lorenza;Teofili, Luciana;Capodimonti, Sara;Nuzzolo, Eugenia Rosa;Iachininoto, Maria Grazia;Massini, Giuseppina;Zini Tanzi, Gina;Larocca, Luigi Maria
2013
Abstract
Frequent blood loss induces progressive depletion of iron stores, leading to iron deficiency and, ultimately, to overt iron-deficient anaemia. The erythropoietin-mediated bone marrow response to anaemia is under the control of hypoxia-inducible factors (HIF), the master regulators of oxygen and iron homeostasis. Since the HIF-1α(Pro-582-Ser) variant is associated with elevated trans-activation capacity of hypoxia responsive elements of target genes, we investigated whether the HIF-1α(Pro-582-Ser) polymorphism might influence the response to repeated blood withdrawals.
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