Infliximab is effective in human and murine IBD, but its pharmacodynamic is still poorly known. The aim of this study was to assess the affinity of infliximab to murine TNF-α, its role in murine colitis when administered intra-rectally and its levels in the blood, gut mucosa and stool of healthy and sick mice.
Lopetuso, L. R., Petito, V., Cufino, V., Arena, V., Stigliano, E., Gerardi, V., Gaetani, E., Poscia, A., Amato, A., Cammarota, G., Papa, A., Sgambato, A., Gasbarrini, A., Scaldaferri, F., Locally injected Infliximab ameliorates murine DSS colitis: differences in serum and intestinal levels of drug between healthy and colitic mice, <<DIGESTIVE AND LIVER DISEASE>>, 2013; 45 (12): 1017-1021. [doi:10.1016/j.dld.2013.06.007] [http://hdl.handle.net/10807/52243]
Locally injected Infliximab ameliorates murine DSS colitis: differences in serum and intestinal levels of drug between healthy and colitic mice
Lopetuso, Loris Riccardo;Petito, Valentina;Cufino, Valerio;Arena, Vincenzo;Stigliano, Egidio;Gerardi, Viviana;Gaetani, Eleonora;Poscia, Andrea;Amato, Arianna;Cammarota, Giovanni;Papa, Alfredo;Sgambato, Alessandro;Gasbarrini, Antonio;Scaldaferri, Franco
2013
Abstract
Infliximab is effective in human and murine IBD, but its pharmacodynamic is still poorly known. The aim of this study was to assess the affinity of infliximab to murine TNF-α, its role in murine colitis when administered intra-rectally and its levels in the blood, gut mucosa and stool of healthy and sick mice.
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