Many experimental evidences point out the correlation between the presence of aluminum-ferritin complex and neursopathological disorders. In these complexes, two different ranges of Aluminium (Al) atoms are usually found, i.e., just few atoms or several hundreds. Here, we investigated the invitro Al-apoferritin binding, with the aim to elucidate the mechanism behind the formation of Alferritin complexes in-vivo. To this purpose, we studied the mineralization of Al in its ionic and complexed form with citrate demonstrating that high Al levels found in clinical studies can be obtained only conveying Al by small physiological ligands.
Chiarpotto, M., Ciasca, G., Vassalli, M., Rossi, C., Campi, G., Ricci, A., Beatrice, B., Pino, A., Alessandro, A., De Sole, P., Papi, M., Mechanism of aluminium bio-mineralization in the apoferritin cavity, <<APPLIED PHYSICS LETTERS>>, 2013; 2013 (103): 1-5. [doi:10.1063/1.4818749] [http://hdl.handle.net/10807/52060]
Mechanism of aluminium bio-mineralization in the apoferritin cavity
Chiarpotto, Michela;Ciasca, Gabriele;Rossi, Cristina;De Sole, Pasquale;Papi, Massimiliano
2013
Abstract
Many experimental evidences point out the correlation between the presence of aluminum-ferritin complex and neursopathological disorders. In these complexes, two different ranges of Aluminium (Al) atoms are usually found, i.e., just few atoms or several hundreds. Here, we investigated the invitro Al-apoferritin binding, with the aim to elucidate the mechanism behind the formation of Alferritin complexes in-vivo. To this purpose, we studied the mineralization of Al in its ionic and complexed form with citrate demonstrating that high Al levels found in clinical studies can be obtained only conveying Al by small physiological ligands.
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